Brandon Jacobs could be set to make debut with 49ers

Brandon Jacobs will be a game-day decision for the San Francisco 49ers as the running back believes he is ready to roll since suffering a knee injury in Week 2 of preseason.

Jacobs took a helmet to his left knee in an exhibition game at Houston but could make his regular-season debut with the 49ers on Sunday against the Buffalo Bills. He had full participation in practice this week for the first time, according to the San Francisco Chronicle. He is listed as questionable.

The 49ers have the third-ranked rushing offense in the NFL right now and Jacobs could add some muscle to the short yardage and goalline packages while also spelling Frank Gore from time to time.

"I'm still thinking about it a little bit, but I'm explosive and I feel good out there," he said. "Practice is one thing, because you've got no adrenaline flowing and you think about everything. You don't think about your injury in a game."

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Brad Biggs covers the Bears for the Chicago Tribune