Indianapolis Colts defensive end Robert Mathis will miss two to three weeks with a knee injury, according to the Indianapolis Star.

Mathis suffered the injury in Sunday's win over the Green Bay Packers. He traveled to Atlanta to get a second opinion on the knee, but will miss some time. The Colts' other defensive end, Dwight Freeney, has missed time with a sprained ankle, but returned in the game against Green Bay.

The Colts are already without running back Donald Brown, who will miss time following surgery to repair cartilage damage in his knee.

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Terry McCormick covers the Titans for TitanInsider.com