Peyton Manning is dealing with a pain in the butt, literally.

The Indianapolis Colts' star quarterback was limited in practice today because of a glute injury.

Manning has never a missed a start in a dozen seasons.

The Colts listed 25 players on their injury report, including 13 starters.

Manning was one of 25 players and 13 starters on the Colts' long list of injuries.

Four starters were sidelined at practice, including: wide receiver Reggie Wayne (foot), defensive end Dwight Freeney (abdomen), safety Antoine Bethea (foot) and cornerback Kelvin Hayden (knee).

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