Mike Iupati, Patrick Willis out for 49ers
San Francisco 49ers offensive guard Mike Iupati is out with a concussion for Sunday's game against the Denver Broncos.
Iupati will be replaced in the starting lineup by Joe Looney.
Middle linebacker Patrick Willis is out with a toe injury.
He could return for a Nov. 2 game against the St. Louis Rams.
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Aaron Wilson covers the Ravens for The Baltimore Sun