Sep 16, 2023; Boulder, Colorado, USA; Colorado Buffaloes quarterback Shedeur Sanders (2) and head coach Deion Sanders following a two point conversion in the fourth quarter against the Colorado State Rams at Folsom Field. Mandatory Credit: Ron Chenoy-USA TODAY Sports

College football Week 4 picks

College football Week 4 picks sees a trio of marque matchups and one where our experts see a comeuppance happening – that would be Colorado facing Oregon.

Check out the picks and watch for bonus specials and odds boosts at Draft Kings Sportsbook!

Colorado at Oregon (-21)

Deion Sanders’ Colorado revamp continued to find success last week in the Buffaloes 43-35 double overtime win over Colorado State. Their short winning streak should end this week and history is also against them covering. The Buffaloes are 4-11 ATS in their last 15 games, and 1-6 ATS on the road as an underdog. Against conference opponents Colorado has lost six straight overall and four in a row ATS

Oregon dominated Hawaii in a 55-10 win as 38-point favorites last week to improve to 3-0 ATS on the season. At home the Ducks are tough with a 9-1 record both SU and ATS in their last 10, and a 19-1 SU and 11-9 ATS mark in their last 20. Against Colorado the Ducks are 9-1 SU and 8-2 ATS in their last 10.

Pick: Oregon -21

Ohio State at Notre Dame (+3)

The Buckeyes posted their first ATS win last week after crushing Western Kentucky 63-10 as 29.5-point favorites. Don’t expect another cover this week. Ohio State has been a bad road bet lately at 1-6 ATS in their last seven. Worth noting, they were favored in all seven games.

The Fighting Irish are always tough at home with a 17-3 SU record in their last 20 games. They’re equally as tough as a home underdog with a 5-1 record SU and ATS in their last six games. Versus opponents from the Big Ten the Fight Irish are 5-1-1 ATS in their last seven.

Pick: Notre Dame +3.5

Ole Miss at Alabama (-7)

Alabama continued to disappoint bettors last week in their 17-3 win over South Florida as 34.5-point favorites. You don’t have to be a math genius to figure out they didn’t even come close to covering that one, and we expect the same this weekend. The Crimson Tide laid an egg at home earlier this season in a loss to Texas that halted their lengthy home winning streak. In their last 10 at home Alabama is 9-1 SU but only 5-4-1 ATS. They’re 2-4-1 ATS in their last seven overall.

Ole Miss is 3-0 SU and ATS this season after drubbing Georgia Tech 48-23 as 17-point favorites last week. As underdogs they’ve won three straight ATS and last season against Alabama they delivered an ATS win in a 30-24 loss as 11-point underdogs. In their last seven versus the Crimson Tide they’re 4-3 ATS.

Pick: Ole Miss +7

Upcoming Games

Aug 24th, 12:00 PM

Florida State (6) -13 -115

Georgia Tech +13 -115

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Aug 24th, 3:33 PM

Delaware State

Hawaii

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Aug 24th, 3:33 PM

SMU (22)

Nevada

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Aug 24th, 3:33 PM

Montana State

New Mexico

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Aug 29th, 3:33 PM

Alcorn State

UAB

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Southeastern Louisiana

Tulane

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Northwestern State

Tulsa

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Sacramento State

San Jose State

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Lindenwood

Kansas (23)

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New Hampshire

UCF

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Southern Utah

Utah

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Lafayette

Buffalo

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Duquesne

Toledo

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Fordham

Bowling Green

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Central Connecticut State

Central Michigan

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North Carolina

Minnesota

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Western Carolina

NC State (21)

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North Carolina A&T

Wake Forest

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Eastern Illinois

Illinois

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Coastal Carolina

Jacksonville State

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Arkansas-Pine Bluff

Arkansas

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Murray State

Missouri (8)

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Jackson State

Louisiana-Monroe

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North Dakota State +10 -115

Colorado -10 -115

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Aug 30th, 3:33 PM

Elon

Duke

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Lehigh

Army

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Temple

Oklahoma (15)

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Aug 30th, 10:30 PM

TCU

Stanford

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Aug 31st, 12:00 PM

Georgia (4) -11.5 -115

Clemson (20) +11.5 -115

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Aug 31st, 3:00 PM

Portland State

Washington State

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Colorado State

Texas (3)

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Miami-FL

Florida

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James Madison

Charlotte

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Norfolk State

East Carolina

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Florida Atlantic

Michigan State

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North Alabama

Memphis

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Bucknell

Navy

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North Texas

South Alabama

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Sam Houston State

Rice

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Bethune-Cookman

USF

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Kennesaw State

UTSA

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Merrimack

Air Force

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Boise State

Georgia Southern

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UCLA

Hawaii

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Nevada

Troy

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New Mexico

Arizona (11)

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Texas A&M-Commerce

San Diego State

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UNLV

Houston

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Robert Morris

Utah State

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Wyoming

Arizona State

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Alabama A&M

Auburn

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Furman

Ole Miss (9)

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Eastern Kentucky

Mississippi State

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Old Dominion

South Carolina

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Chattanooga

Tennessee (17)

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Virginia Tech

Vanderbilt

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Southern Miss

Kentucky

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East Tennessee State

Appalachian State

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Georgia State

Georgia Tech

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Stony Brook

Marshall

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Grambling State

Louisiana-Lafayette

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Lamar

Texas State

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Southern Illinois

BYU

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South Dakota State

Oklahoma State (16)

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Abilene Christian

Texas Tech

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Penn State (13)

West Virginia

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Tarleton

Baylor

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North Dakota

Iowa State

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Towson

Cincinnati

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Tennessee-Martin

Kansas State (18)

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Akron

Ohio State (10)

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Eastern Michigan

Massachusetts

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Kent State

Pittsburgh

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Miami-OH

Northwestern

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Western Illinois

NIU

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Ohio

Syracuse

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Western Michigan

Wisconsin

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UC Davis

California

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Austin Peay

Louisville (19)

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Houston Baptist

SMU (22)

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Richmond

Virginia

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Florida International (FIU)

Indiana

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Campbell

Liberty (25)

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Nicholls State

LA Tech

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Tennessee Tech

Middle Tennessee

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Southeast Missouri State

New Mexico State

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UTEP

Nebraska

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Illinois State

Iowa (24)

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UCONN

Maryland

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Idaho

Oregon (6)

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Howard

Rutgers

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Weber State

Washington (2)

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Indiana State

Purdue

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Idaho State

Oregon State

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WKU

Alabama (5)

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Central Arkansas

Arkansas State

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Fresno State

Michigan (1)

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Notre Dame (14) +3 -115

Texas A&M -3 -115

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