Sep 16, 2023; Boulder, Colorado, USA; Colorado Buffaloes quarterback Shedeur Sanders (2) and head coach Deion Sanders following a two point conversion in the fourth quarter against the Colorado State Rams at Folsom Field. Mandatory Credit: Ron Chenoy-USA TODAY Sports

College football Week 4 picks

College football Week 4 picks sees a trio of marque matchups and one where our experts see a comeuppance happening – that would be Colorado facing Oregon.

Check out the picks and watch for bonus specials and odds boosts at Draft Kings Sportsbook!

Colorado at Oregon (-21)

Deion Sanders’ Colorado revamp continued to find success last week in the Buffaloes 43-35 double overtime win over Colorado State. Their short winning streak should end this week and history is also against them covering. The Buffaloes are 4-11 ATS in their last 15 games, and 1-6 ATS on the road as an underdog. Against conference opponents Colorado has lost six straight overall and four in a row ATS

Oregon dominated Hawaii in a 55-10 win as 38-point favorites last week to improve to 3-0 ATS on the season. At home the Ducks are tough with a 9-1 record both SU and ATS in their last 10, and a 19-1 SU and 11-9 ATS mark in their last 20. Against Colorado the Ducks are 9-1 SU and 8-2 ATS in their last 10.

Pick: Oregon -21

Ohio State at Notre Dame (+3)

The Buckeyes posted their first ATS win last week after crushing Western Kentucky 63-10 as 29.5-point favorites. Don’t expect another cover this week. Ohio State has been a bad road bet lately at 1-6 ATS in their last seven. Worth noting, they were favored in all seven games.

The Fighting Irish are always tough at home with a 17-3 SU record in their last 20 games. They’re equally as tough as a home underdog with a 5-1 record SU and ATS in their last six games. Versus opponents from the Big Ten the Fight Irish are 5-1-1 ATS in their last seven.

Pick: Notre Dame +3.5

Ole Miss at Alabama (-7)

Alabama continued to disappoint bettors last week in their 17-3 win over South Florida as 34.5-point favorites. You don’t have to be a math genius to figure out they didn’t even come close to covering that one, and we expect the same this weekend. The Crimson Tide laid an egg at home earlier this season in a loss to Texas that halted their lengthy home winning streak. In their last 10 at home Alabama is 9-1 SU but only 5-4-1 ATS. They’re 2-4-1 ATS in their last seven overall.

Ole Miss is 3-0 SU and ATS this season after drubbing Georgia Tech 48-23 as 17-point favorites last week. As underdogs they’ve won three straight ATS and last season against Alabama they delivered an ATS win in a 30-24 loss as 11-point underdogs. In their last seven versus the Crimson Tide they’re 4-3 ATS.

Pick: Ole Miss +7

Upcoming Games

Dec 9th, 3:00 PM

Army -2.5 -110

Navy +2.5 -110


Dec 16th, 11:00 AM

Ohio -2.5 -115

Georgia Southern +2.5 -115


Dec 16th, 2:15 PM

Jacksonville State +1.5 +100

Louisiana-Lafayette -1.5 +100


Dec 16th, 3:30 PM

Appalachian State -4.5 -105

Miami-OH +4.5 -105


Dec 16th, 5:45 PM

Fresno State -1.5 -110

New Mexico State +1.5 -110


Dec 16th, 7:30 PM

Boise State +2.5 -115

UCLA -2.5 -115


Dec 16th, 9:15 PM

California -1.5 -122

Texas Tech +1.5 -122