Oct 23, 2021; South Bend, Indiana, USA; Notre Dame Fighting Irish wide receiver Lorenzo Styles Jr. (21) runs the ball as USC Trojans safety Xavion Alford (29) attempts to tackle in the second quarter at Notre Dame Stadium. Mandatory Credit: Matt Cashore-USA TODAY Sports

College football Week 7 picks: Notre Dame vs USC

The annual Notre vs USC tilt highlights our Week 7 college football picks lineup. Watch for the latest lines and awesome bonus specials for new players at Draft Kings Sportsbook.

Oregon at Washington (-3)

Oregon has been perfect for bettors so far this season at 5-0 against the spread. Unfortunately, that perfect streak will end this weekend as underdogs. The Ducks have lost five in a row as underdogs both straight up and ATS. Last season the Ducks were 12-point favorites versus Washington and lost 37-34.

Washington is coming off their bye week. In their last seven game after their bye week at home they’re 7-2 SU. Overall the Huskies have won 12 straight with a 7-5 ATS record. At home they’re unbeaten in 10 at 7-3 ATS.

Pick: Washington -3

USC at Notre Dame (-2.5)

USC has been a bad bet lately with three straight loss ATS including last week’s 42-41 win over Arizona as 21-point favorites. The smart bet may be to take the Over on the total as thanks to their stout offense and mediocre defense USC is 13-1 Over in their last 14 games. As an underdog the Trojans have lost nine straight at 3-6 ATS.

Notre Dame dropped the ball last week in a 33-20 loss to Louisville as 6.5-point road favorites. At home the Fighting Irish are 5-1 SU and 3-2-1 ATS in their last six. And, versus the Trojans in South Bend they’ve won five straight at 4-1 ATS

Pick: Notre Dame -2.5

Miami at North Carolina (-4)

Miami literally fumbled away a win over Georgia Tech last week. Even if the Hurricanes had done the smart thing an took a knee in the fourth quarter last week in their 23-20 loss they still would not have covered the 19-point spread. In their last eight road games Miami is a lackluster 3-5 ATS. In conference matchups they’re a lousy 1-8 ATS in their last nine.

North Carolina is a solid 4-1 ATS after last week’s 40-7 beatdown of Syracuse as 9.5-point favorites. The Tar Heels have won five straight when favored with a 4-1 ATS mark. Last season they defeated Miami 27-24 as 4-point underdogs, and they’re 7-2 ATS in their last nine against them.

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