Aug 22, 2021; Inglewood, California, USA; San Francisco 49ers quarterback Jimmy Garoppolo (10) throws the ball under pressure from Los Angeles Chargers linebacker Kyler Fackrell (52) in the first quarter at SoFi Stadium. Mandatory Credit: Kirby Lee-USA TODAY Sports

Chargers 49ers Pick, LA Covers 7

The Los Angeles Chargers are just looking for simple. They haven’t had a nice clean win since beating the lowly Texans more than a month ago. Unfortunately, their road trip continues Sunday night in San Francisco.

With 49ers favored by seven points, let’s look at both sides.

Chargers 49ers Pick: Odds SF -7, Total 45.5 | Matchup Stats


Draft Kings sportsbook

Rated 5/5

100% BONUS UP TO $1000

A pioneer in the sports betting space, one of just three wagering partners hand-picked by the NFL and a lively mobile product full of great odds and betting variety. Check out Draft Kings today.


Kyle Juszczyk, Deebo Samuel, Arik Armstead, Dre Greenlaw and several other key 49ers are hurt, so the Chargers have a health advantage even with the status of Mike Williams and Keenan Allen up in the air. They’re also a very competitive team getting a lot of points.


They should be healthier coming off the bye week, and even before that they smashed the Rams. San Francisco just has so many weapons when healthy that it’ll be hard for the Bolts to keep up.


The Chargers have lost by seven-plus points just once in their last 10 games. They hang. And they’ll do that here.

49ers Chargers Props – Anytime TD Picks

Brandon Aiyuk +195

Aiyuk had three touchdowns in his last three games. At these odds, this is great value.

Josh Palmer +220

With Mike Williams and Keenan Allen out, Palmer slots in as the top receiver on the Chargers and should get red-zone attention alongside Austin Ekeler.

49ers Chargers Betting Trends

Chargers are 5-0 SU in their last 5 games against San Francisco.

49ers are 6-1 ATS in their last 7 games at home.

Chargers are 10-4 ATS in their last 14 games on the road.

Chargers are 1-8 SU, 2-7 ATS in their last 9 games played in Week 10.

UNDER is 9-1 San Francisco’s last 10 games as the favorite.

49ers are just 2-8 ATS past 10 seasons following bye week



Rated 5/5

Rated 5/5

Upcoming Games

Aug 1st, 8:00 PM




Aug 8th, 7:00 PM


New England


Aug 8th, 7:00 PM


NY Giants