Jan 30, 2022; Inglewood, California, USA; Los Angeles Rams quarterback Matthew Stafford (9) throws a pass against the San Francisco 49ers in the first half during the NFC Championship Game at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-USA TODAY Sports

Rams 49ers Betting Prediction, MNF Dog & UNDER?

There is plenty of star power in this NFC West battle but the injury to a lesser-known commodity will decide this Week 4 Monday Nighter in favor of the LA Rams.

That absence is OT Trent Williams, the league’s top offensive lineman and quiet architect of the San Francisco ground attack. Without him, it’s a tough slog for the running backs which forces Jimmy Garoppolo into a bigger role than he wants.

Both teams play heavy and hard on defense and this game could be another MNF UNDER play.

Rams 49ers Betting Prediction: SF -1.5, Total 42.5 | Matchup Stats

Draft Kings sportsbook

Rated 5/5

100% BONUS UP TO $1000

A pioneer in the sports betting space, one of just three wagering partners hand-picked by the NFL and a lively mobile product full of great odds and betting variety. Check out Draft Kings today.

Why the Rams can Cover

LA has lost six straight regular-season games to the 49ers, but vanquished them in the playoffs, which may have started a new streak. The Rams run defense ranks 10th at the moment and San Francisco will find it tougher in the trenches minus Williams.

Matthew Stafford has more INTs than TDs this year, but an improving ground game combined with Cooper Kupp dual threat (he is -135 to score a TD at FanDuel) suggests they can move the ball. The DL is gonna get after Jimmy G hard.

For some reason, the 49ers like to lose in Week 4 – six seasons in a row.

Why the 49ers can Cover

San Fran has dominated the Rams, but counting on Jimmy G after his Week 3 performance against the Broncos is being risky with your cash. Still, the defense ranks Top 5 in most categories and can keep this thing tight.

They own an 11-3 ATS mark over 14 games with the Rams and have been an excellent Monday Night bet (14-4 ATS past 18 games).

Rams 49ers Betting Prediction

We like the Rams to resume their own streak against the 49ers here, probably in a low-scoring game. The 49ers have played 10 UNDERs in 11 games. This feels like 17-13 or something, making us more comfortable with the UNDER 42.5 than the spread. If you want to bet both, we play dog and UNDER.

Rams 49ers Betting Trends

UNDER is 10-1 San Francisco’s last 11 games.

49ers are 11-3 ATS in their last 14 games against LA Rams.

Rams are 4-1 ATS in their last 5 games played on a Monday.

OVER is 16-6 LA Rams’ last 22 games as the underdog.

49ers have lost 6 straight Week 4 games – why? No idea.

49ers are 14-4 ATS in their last 18 games played on a Monday.

Bet Rams 49ers

Rated 5/5

Rated 5/5

Rated 5/5

Upcoming Games