The 49ers have looked dominant but not as dominant as the Giants were in the second half of Week 2. The problem with handicapping the Week 3 Thursday Nighter is that the Giants were outscored 60-0 in the first six quarters of the season so are they on a roll or just rallying against a terrible Cardinals team?
A Giants 49ers pick here depends on how you view New York and whether 10.5 points is a gift from oddsmakers or a trap.
San Francisco has won 13 straight as favorites and have been dominant against the spread at home (13-2 ATS) and in conference games (17-4 ATS).
Giants 49ers Pick: Odds SF -10.5, Total 45 at Draft Kings | Matchup Report