Oct 24, 2020; Clemson, South Carolina, USA;   Clemson quarterback Trevor Lawrence (16) waves to fans after their game against Syracuse at Memorial Stadium. Mandatory Credit: Ken Ruinard-USA TODAY Sports

Clemson vs Notre Dame: opening lines report

Week 10 in college football features two interesting ranked matchups, including to Top 10 teams squaring off and a Top 5 matchup that could have future playoff implications.

The Top 5 matchup pits the No. 1 Clemson Tigers against the No. 4 Notre Dame Fighting Irish. When the lines were first posted the Tigers were listed as a 7.5-point road favorite, but that was quickly bet down to -5.5 by Monday.

Last week, without starting quarterback Trevor Lawrence, sidelined by COVID-19, the Tigers escaped with a 34-28 win over the Boston College Eagles as a 26.5-point favorite. The Fighting Iris have won their last three games as a home underdog. [ Matchup Report and Game Props

College Football opening lines

In the other notable ranked matchup the No. 8 Florida Gators take on the No. 5 Georgia Bulldogs. The opening odds for this game peg the Bulldogs as a 2.5-point favorite. Georgia has won their last three games against Florida both straight up and against the spread. [ Matchup Report and live odds

The largest spread on the early odds list this week belongs to the Marshall Thundering Herd. They’re a 43.5-point home favorite versus the Massachusetts Minutemen. Marshall heads into this game having won five straight at 4-1 ATS.

Two other games on the schedule this week also boast spreads of 20 points or high. First up, the Oklahoma Sooners opened as a 37-point home favorite against the Kansas Jayhawks. In their last 22 games when favored by 37 points or more the Sooners are 22-0 SU and 14-7-1 ATS.

In the Big Ten the Penn State Nittany Lions opened as a 24.5-point home favorite versus the Maryland Terrapins. Penn state has gotten off to a lousy start this season, losing their first two games SU. They’re also 2-5 ATS in their last seven.

The early odds included 16 road teams listed as the favorite this week. The largest road favorite when the lines opener were the Appalachian State Mountaineers. They opened as a 17-point road favorite against the Texas State Bobcats. The Mountaineers have faced large spread in almost every game this season, and they’ve disappointed bettors with a 1-4 ATS record.

Also noteworthy for bettors this week is the return of the Pac-12. They kickoff their season this weekend and a few opening lines included Washington at California (+3.5), and Washington State at Oregon State (-3).

Get live college football odds updated for every game as well as statistical breakdowns for every game.

Upcoming Games

Sep 30th, 7:30 PM

Virginia +4 -110

Miami-FL -4 -110

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Oct 1st, 7:30 PM

Houston +4 -110

Tulsa -4 -110

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Oct 1st, 8:00 PM

Iowa (5) -3 +100

Maryland +3 +100

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Oct 1st, 9:00 PM

BYU (13) -7.5 -110

Utah State +7.5 -110

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Oct 2nd, 12:00 PM

Arkansas (8) +18.5 -107

Georgia (2) -18.5 -107

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Oct 2nd, 12:00 PM

Tennessee +3 -107

Missouri -3 -107

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Oct 2nd, 12:00 PM

Pittsburgh -3.5 -107

Georgia Tech +3.5 -107

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Oct 2nd, 12:00 PM

Western Michigan -6.5 -110

Buffalo +6.5 -110

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Oct 2nd, 12:00 PM

Texas -5 -110

TCU +5 -110

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Oct 2nd, 12:00 PM

Duke +16 -110

North Carolina -16 -110

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Oct 2nd, 12:00 PM

Toledo -26.5 -107

Massachusetts +26.5 -107

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Oct 2nd, 12:00 PM

Charlotte +9 -107

Illinois -9 -107

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Oct 2nd, 12:00 PM

Memphis -11.5 -107

Temple +11.5 -107

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Oct 2nd, 12:00 PM

Minnesota +2.5 -107

Purdue -2.5 -107

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Oct 2nd, 12:00 PM

Michigan (14) +4.5 -107

Wisconsin -4.5 -107

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Oct 2nd, 12:30 PM

Louisville +7 +103

Wake Forest (24) -7 +103

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Oct 2nd, 2:00 PM

Appalachian State -9 -107

Georgia State +9 -107

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Oct 2nd, 2:00 PM

USC -6.5 -107

Colorado +6.5 -107

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Oct 2nd, 2:30 PM

Louisiana-Monroe +31.5 -110

Coastal Carolina (16) -31.5 -110

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Oct 2nd, 2:30 PM

Eastern Michigan +2 -110

NIU -2 -110

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Oct 2nd, 2:30 PM

Cincinnati (7) +1.5 -107

Notre Dame (9) -1.5 -107

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Oct 2nd, 3:30 PM

Troy +8.5 -107

South Carolina -8.5 -107

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Oct 2nd, 3:30 PM

Ole Miss (12) +16.5 -110

Alabama (1) -16.5 -110

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Oct 2nd, 3:30 PM

Oregon (3) -7 -107

Stanford +7 -107

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Oct 2nd, 3:30 PM

Florida International (FIU) +10 -110

Florida Atlantic -10 -110

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Oct 2nd, 3:30 PM

Syracuse +3.5 -110

Florida State -3.5 -110

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Oct 2nd, 3:30 PM

Bowling Green +14.5 -107

Kent State -14.5 -107

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Oct 2nd, 3:30 PM

Central Michigan +1 -107

Miami-OH -1 -107

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Oct 2nd, 3:30 PM

Ohio -9 -107

Akron +9 -107

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Oct 2nd, 3:30 PM

Texas Tech +7 -110

West Virginia -7 -110

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Oct 2nd, 3:30 PM

Oklahoma (6) -9.5 -110

Kansas State +9.5 -110

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Oct 2nd, 3:30 PM

UCF -14 -107

Navy +14 -107

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Oct 2nd, 3:30 PM

Nevada +6 -110

Boise State -6 -110

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Oct 2nd, 3:30 PM

Tulane -3.5 -110

East Carolina +3.5 -110

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Oct 2nd, 3:30 PM

Ohio State (11) -14.5 -110

Rutgers +14.5 -110

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Oct 2nd, 4:00 PM

Arkansas State +3.5 -110

Georgia Southern -3.5 -110

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Oct 2nd, 4:00 PM

USF +19.5 -107

SMU -19.5 -107

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Oct 2nd, 5:00 PM

Army -7.5 -107

Ball State +7.5 -107

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Oct 2nd, 5:30 PM

Washington State +7 -107

California -7 -107

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Oct 2nd, 6:00 PM

Florida (10) -7.5 -107

Kentucky +7.5 -107

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Oct 2nd, 6:00 PM

UNLV +19 -110

UTSA -19 -110

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Oct 2nd, 6:00 PM

LA Tech +19.5 -107

NC State (23) -19.5 -107

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Oct 2nd, 6:30 PM

Southern Miss +3 -107

Rice -3 -107

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Oct 2nd, 6:30 PM

Air Force -10.5 -110

New Mexico +10.5 -110

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Oct 2nd, 7:00 PM

Kansas +32.5 -107

Iowa State -32.5 -107

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Oct 2nd, 7:00 PM

Mississippi State +9 -110

Texas A&M (15) -9 -110

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Oct 2nd, 7:00 PM

Baylor (21) +3.5 -107

Oklahoma State (19) -3.5 -107

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Oct 2nd, 7:00 PM

Marshall -10.5 -107

Middle Tennessee +10.5 -107

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Oct 2nd, 7:00 PM

Liberty +1.5 -107

UAB -1.5 -107

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Oct 2nd, 7:30 PM

Boston College +14.5 -110

Clemson (25) -14.5 -110

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Oct 2nd, 7:30 PM

UCONN +13.5 -110

Vanderbilt -13.5 -110

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Oct 2nd, 7:30 PM

WKU +8 -107

Michigan State (17) -8 -107

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Oct 2nd, 7:30 PM

Northwestern +10 -107

Nebraska -10 -107

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Oct 2nd, 7:30 PM

Indiana +10.5 -107

Penn State (4) -10.5 -107

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Oct 2nd, 8:00 PM

Louisiana-Lafayette -9.5 -107

South Alabama +9.5 -107

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Oct 2nd, 9:00 PM

Washington -3 -107

Oregon State +3 -107

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Oct 2nd, 9:00 PM

Auburn (22) +3.5 -110

LSU -3.5 -110

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Oct 2nd, 9:00 PM

Old Dominion +3.5 -107

UTEP -3.5 -107

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Oct 2nd, 10:30 PM

Arizona State +3.5 -107

UCLA (20) -3.5 -107

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Oct 2nd, 10:30 PM

New Mexico State +26 -107

San Jose State -26 -107

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Oct 2nd, 11:00 PM

Fresno State (18) -11 -107

Hawaii +11 -107

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Oct 7th, 7:30 PM

Coastal Carolina (16)

Arkansas State

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Oct 7th, 7:30 PM

Houston

Tulane

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