Oct 24, 2020; Clemson, South Carolina, USA;   Clemson quarterback Trevor Lawrence (16) waves to fans after their game against Syracuse at Memorial Stadium. Mandatory Credit: Ken Ruinard-USA TODAY Sports

Clemson vs Notre Dame: opening lines report

Week 10 in college football features two interesting ranked matchups, including to Top 10 teams squaring off and a Top 5 matchup that could have future playoff implications.

The Top 5 matchup pits the No. 1 Clemson Tigers against the No. 4 Notre Dame Fighting Irish. When the lines were first posted the Tigers were listed as a 7.5-point road favorite, but that was quickly bet down to -5.5 by Monday.

Last week, without starting quarterback Trevor Lawrence, sidelined by COVID-19, the Tigers escaped with a 34-28 win over the Boston College Eagles as a 26.5-point favorite. The Fighting Iris have won their last three games as a home underdog. [ Matchup Report and Game Props

College Football opening lines

In the other notable ranked matchup the No. 8 Florida Gators take on the No. 5 Georgia Bulldogs. The opening odds for this game peg the Bulldogs as a 2.5-point favorite. Georgia has won their last three games against Florida both straight up and against the spread. [ Matchup Report and live odds

The largest spread on the early odds list this week belongs to the Marshall Thundering Herd. They’re a 43.5-point home favorite versus the Massachusetts Minutemen. Marshall heads into this game having won five straight at 4-1 ATS.

Two other games on the schedule this week also boast spreads of 20 points or high. First up, the Oklahoma Sooners opened as a 37-point home favorite against the Kansas Jayhawks. In their last 22 games when favored by 37 points or more the Sooners are 22-0 SU and 14-7-1 ATS.

In the Big Ten the Penn State Nittany Lions opened as a 24.5-point home favorite versus the Maryland Terrapins. Penn state has gotten off to a lousy start this season, losing their first two games SU. They’re also 2-5 ATS in their last seven.

The early odds included 16 road teams listed as the favorite this week. The largest road favorite when the lines opener were the Appalachian State Mountaineers. They opened as a 17-point road favorite against the Texas State Bobcats. The Mountaineers have faced large spread in almost every game this season, and they’ve disappointed bettors with a 1-4 ATS record.

Also noteworthy for bettors this week is the return of the Pac-12. They kickoff their season this weekend and a few opening lines included Washington at California (+3.5), and Washington State at Oregon State (-3).

Get live college football odds updated for every game as well as statistical breakdowns for every game.

Upcoming Games

Aug 28th, 3:33 PM

Hawaii

UCLA

@

Aug 28th, 3:33 PM

Southern Utah

San Jose State (24)

@

Aug 28th, 3:33 PM

Nebraska

Illinois

@

Aug 28th, 3:33 PM

UCONN

Fresno State

@

Aug 28th, 3:33 PM

UTEP

New Mexico State

@

Sep 1st, 3:33 PM

Jacksonville State

UAB

@

Sep 2nd, 12:00 PM

East Carolina

Appalachian State

@

Sep 2nd, 3:33 PM

LIU

Florida International (FIU)

@

Sep 2nd, 3:33 PM

Weber State

Utah

@

Sep 2nd, 3:33 PM

Southern Utah

Arizona State

@

Sep 2nd, 3:33 PM

Western Illinois

Ball State (23)

@

Sep 2nd, 3:33 PM

North Carolina (18)

Virginia Tech

@

Sep 2nd, 3:33 PM

USF

NC State

@

Sep 2nd, 3:33 PM

UC Davis

Tulsa

@

Sep 2nd, 3:33 PM

Ohio State (2)

Minnesota

@

Sep 2nd, 3:33 PM

Houston Baptist

New Mexico

@

Sep 2nd, 3:33 PM

Eastern Washington

UNLV

@

Sep 3rd, 3:33 PM

Northern Colorado

Colorado

@

Sep 3rd, 3:33 PM

St. Francis-PA

Eastern Michigan

@

Sep 3rd, 3:33 PM

Old Dominion

Wake Forest

@

Sep 4th, 3:33 PM

Clemson (3)

Georgia (7)

@

Sep 4th, 3:33 PM

Duke

Charlotte

@

Sep 4th, 3:33 PM

The Citadel

Coastal Carolina (14)

@

Sep 4th, 3:33 PM

Florida Atlantic

Florida (13)

@

Sep 4th, 3:33 PM

Central Michigan

Missouri

@

Sep 4th, 3:33 PM

Colgate

Boston College

@

Sep 4th, 3:33 PM

Montana

Washington

@

Sep 4th, 3:33 PM

Northern Iowa

Iowa State (9)

@

Sep 4th, 3:33 PM

Louisiana-Monroe

Kentucky

@

Sep 4th, 3:33 PM

Bowling Green

Tennessee

@

Sep 4th, 3:33 PM

Fresno State

Oregon

@

Sep 4th, 3:33 PM

Eastern Illinois

South Carolina

@

Sep 4th, 3:33 PM

Army

Georgia State

@

Sep 4th, 3:33 PM

East Tennessee State

Vanderbilt

@

Sep 4th, 3:33 PM

Kansas State

Stanford

@

Sep 4th, 3:33 PM

Kent State

Texas A&M (4)

@

Sep 4th, 3:33 PM

Akron

Auburn

@

Sep 4th, 3:33 PM

Utah State

Washington State

@

Sep 4th, 3:33 PM

Southern University

Troy

@

Sep 4th, 3:33 PM

Rice

Arkansas

@

Sep 4th, 3:33 PM

NIU

Georgia Tech

@

Sep 4th, 3:33 PM

Nevada

California

@

Sep 4th, 3:33 PM

Missouri State

Oklahoma State (20)

@

Sep 4th, 3:33 PM

LA Tech

Mississippi State

@

Sep 4th, 3:33 PM

Monmouth-New Jersey

Middle Tennessee

@

Sep 4th, 3:33 PM

San Jose State (24)

USC (21)

@

Sep 4th, 3:33 PM

Southern Miss

South Alabama

@

Sep 4th, 3:33 PM

Northwestern State

North Texas

@

Sep 4th, 3:33 PM

Louisiana-Lafayette (15)

Texas (19)

@

Sep 4th, 3:33 PM

Wagner

Buffalo (25)

@

Sep 4th, 3:33 PM

Baylor

Texas State

@

Sep 4th, 3:33 PM

Syracuse

Ohio

@

Sep 4th, 3:33 PM

Alabama (1)

Miami-FL (22)

@

Sep 4th, 3:33 PM

Duquesne

TCU

@

Sep 4th, 3:33 PM

Central Arkansas

Arkansas State

@

Sep 4th, 3:33 PM

Norfolk State

Toledo

@

Sep 4th, 3:33 PM

LSU

UCLA

@

Sep 4th, 3:33 PM

Arizona

BYU (11)

@

Sep 4th, 3:33 PM

Bethune-Cookman

UTEP

@

Sep 4th, 3:33 PM

Campbell

Liberty (17)

@

Sep 4th, 3:33 PM

Tennessee-Martin

WKU

@

Sep 4th, 3:33 PM

Miami-OH

Cincinnati (8)

@

Sep 4th, 3:33 PM

Holy Cross

UCONN

@

Sep 4th, 3:33 PM

Houston

Texas Tech

@

Sep 4th, 3:33 PM

Nicholls State

Memphis

@

Sep 4th, 3:33 PM

Massachusetts

Pittsburgh

@

Sep 4th, 3:33 PM

Boise State

UCF

@

Sep 4th, 3:33 PM

William & Mary

Virginia

@

Sep 4th, 3:33 PM

South Dakota

Kansas

@

Sep 4th, 3:33 PM

Abilene Christian

SMU

@

Sep 4th, 3:33 PM

Marshall

Navy

@

Sep 4th, 3:33 PM

Oklahoma (6)

Tulane

@

Sep 4th, 3:33 PM

UTSA

Illinois

@

Sep 4th, 3:33 PM

New Mexico State

San Diego State

@

Sep 4th, 3:33 PM

Portland State

Hawaii

@

Sep 4th, 3:33 PM

Indiana (12)

Iowa (16)

@

Sep 4th, 3:33 PM

West Virginia

Maryland

@

Sep 4th, 3:33 PM

Western Michigan

Michigan

@

Sep 4th, 3:33 PM

Michigan State

Northwestern (10)

@

Sep 4th, 3:33 PM

Lafayette

Air Force

@

Sep 4th, 3:33 PM

Montana State

Wyoming

@

Sep 4th, 3:33 PM

Oregon State

Purdue

@

Sep 4th, 3:33 PM

Temple

Rutgers

@

Sep 4th, 3:33 PM

Penn State

Wisconsin

@

Sep 4th, 3:33 PM

South Dakota State

Colorado State

@

Sep 4th, 6:00 PM

Gardner-Webb

Georgia Southern

@