Nov 7, 2020; Columbus, Ohio, USA; Ohio State Buckeyes quarterback Justin Fields (1) leads the team before the game against the Rutgers Scarlet Knights at Ohio Stadium. Mandatory Credit: Joseph Maiorana-USA TODAY Sports

NCAA Football Opening Lines Report

The opening lines for Week 12 in college football are loaded with large spreads, and there’s also three ranked matchups on the schedule.

Leading the ranked matchups is a Top 10 clash between No. 9 Indiana and No. 3 Ohio State. When Indiana vs Ohio State numbers were set for this game, the Buckeyes listed as a 19.5-point favorite. OSU has won 25 straight against Indiana, but don’t sleep on the Hoosiers here, as they are 7-1 ATS the last 8 times when dogs of 20 or more points.

(Indiana fans can bet the game at BetRivers Indiana)

Big Ten Opening Lines

Staying in the Big Ten, also on tap this week is No. 10 Wisconsin at No. 19 Northwestern. Wisconsin opened as a 7-point road favorite. As a road favorite Wisconsin is 4-2 straight up and ATS in their last six. (Wisconsin Northwestern Matchup Report)

The last ranked matchup in Week 12 is No. 14 Oklahoma State at No. 18 Oklahoma. Oklahoma State may be higher ranked, but they opened as an 8.5-point underdog. Oklahoma has won five straight against their state rivals with a 4-1 ATS record, and at home their 7-1 SU and 5-3 ATS in their last eight versus Oklahoma State.

The largest spread when the opening odds were set this week was in the North Alabama at BYU matchup. BYU opened as a whopping 46-point favorite. When facing a spread of 40 points or higher BYU is 5-0 SU and 3-1-1 ATS in their last five games.

There are five other games with a spread of 30 points or higher this week, starting with Clemson at Florida State. Clemson opened as a 32-point road favorite and when listed as a 30-plus point favorite on the road they’re 3-0 SU, but 0-3 ATS.

Also big road favorites this week is Florida when then visit Vanderbilt. They opened as a 30.5-point road favorite. Florida has only been favored by 30 points or more on the road once in the last 20 years, when they topped Kentucky 44-10 as a 30-point road favorite in 2001.

The other 30-plus point spread on the odds list this week include, Buffalo at Bowling Green (-30), Massachusetts at Florida Atlantic (-30), and tiny Abiliene Christian at Virginia (-35.5).

There are also seven other games with spreads of at least 20 points this week. A select few include Charlotte at Marshall (-21.5), Texas at Kansas (+28.5), Kentucky at Alabama (-29.5) and Mississippi at Georgia (-22.5).

Upcoming Games

Aug 28th, 3:33 PM

Hawaii

UCLA

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Aug 28th, 3:33 PM

Southern Utah

San Jose State (24)

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Aug 28th, 3:33 PM

Nebraska

Illinois

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Aug 28th, 3:33 PM

UCONN

Fresno State

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Aug 28th, 3:33 PM

UTEP

New Mexico State

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Sep 1st, 3:33 PM

Jacksonville State

UAB

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Sep 2nd, 12:00 PM

East Carolina

Appalachian State

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Sep 2nd, 3:33 PM

LIU

Florida International (FIU)

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Sep 2nd, 3:33 PM

Weber State

Utah

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Sep 2nd, 3:33 PM

Southern Utah

Arizona State

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Sep 2nd, 3:33 PM

Western Illinois

Ball State (23)

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Sep 2nd, 3:33 PM

North Carolina (18)

Virginia Tech

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Sep 2nd, 3:33 PM

USF

NC State

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Sep 2nd, 3:33 PM

UC Davis

Tulsa

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Sep 2nd, 3:33 PM

Ohio State (2)

Minnesota

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Sep 2nd, 3:33 PM

Houston Baptist

New Mexico

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Sep 2nd, 3:33 PM

Eastern Washington

UNLV

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Sep 3rd, 3:33 PM

Northern Colorado

Colorado

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Sep 3rd, 3:33 PM

St. Francis-PA

Eastern Michigan

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Sep 3rd, 3:33 PM

Old Dominion

Wake Forest

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Sep 4th, 3:33 PM

Clemson (3)

Georgia (7)

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Sep 4th, 3:33 PM

Duke

Charlotte

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Sep 4th, 3:33 PM

The Citadel

Coastal Carolina (14)

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Sep 4th, 3:33 PM

Florida Atlantic

Florida (13)

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Sep 4th, 3:33 PM

Central Michigan

Missouri

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Sep 4th, 3:33 PM

Colgate

Boston College

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Sep 4th, 3:33 PM

Montana

Washington

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Sep 4th, 3:33 PM

Northern Iowa

Iowa State (9)

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Sep 4th, 3:33 PM

Louisiana-Monroe

Kentucky

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Sep 4th, 3:33 PM

Bowling Green

Tennessee

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Sep 4th, 3:33 PM

Fresno State

Oregon

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Sep 4th, 3:33 PM

Eastern Illinois

South Carolina

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Sep 4th, 3:33 PM

Army

Georgia State

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Sep 4th, 3:33 PM

East Tennessee State

Vanderbilt

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Sep 4th, 3:33 PM

Kansas State

Stanford

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Sep 4th, 3:33 PM

Kent State

Texas A&M (4)

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Sep 4th, 3:33 PM

Akron

Auburn

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Sep 4th, 3:33 PM

Utah State

Washington State

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Sep 4th, 3:33 PM

Southern University

Troy

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Sep 4th, 3:33 PM

Rice

Arkansas

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Sep 4th, 3:33 PM

NIU

Georgia Tech

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Sep 4th, 3:33 PM

Nevada

California

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Sep 4th, 3:33 PM

Missouri State

Oklahoma State (20)

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Sep 4th, 3:33 PM

LA Tech

Mississippi State

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Sep 4th, 3:33 PM

Monmouth-New Jersey

Middle Tennessee

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Sep 4th, 3:33 PM

San Jose State (24)

USC (21)

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Sep 4th, 3:33 PM

Southern Miss

South Alabama

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Sep 4th, 3:33 PM

Northwestern State

North Texas

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Sep 4th, 3:33 PM

Louisiana-Lafayette (15)

Texas (19)

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Sep 4th, 3:33 PM

Wagner

Buffalo (25)

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Sep 4th, 3:33 PM

Baylor

Texas State

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Sep 4th, 3:33 PM

Syracuse

Ohio

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Sep 4th, 3:33 PM

Alabama (1)

Miami-FL (22)

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Sep 4th, 3:33 PM

Duquesne

TCU

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Sep 4th, 3:33 PM

Central Arkansas

Arkansas State

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Sep 4th, 3:33 PM

Norfolk State

Toledo

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Sep 4th, 3:33 PM

LSU

UCLA

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Sep 4th, 3:33 PM

Arizona

BYU (11)

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Sep 4th, 3:33 PM

Bethune-Cookman

UTEP

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Sep 4th, 3:33 PM

Campbell

Liberty (17)

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Sep 4th, 3:33 PM

Tennessee-Martin

WKU

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Sep 4th, 3:33 PM

Miami-OH

Cincinnati (8)

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Sep 4th, 3:33 PM

Holy Cross

UCONN

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Sep 4th, 3:33 PM

Houston

Texas Tech

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Sep 4th, 3:33 PM

Nicholls State

Memphis

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Sep 4th, 3:33 PM

Massachusetts

Pittsburgh

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Sep 4th, 3:33 PM

Boise State

UCF

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Sep 4th, 3:33 PM

William & Mary

Virginia

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Sep 4th, 3:33 PM

South Dakota

Kansas

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Sep 4th, 3:33 PM

Abilene Christian

SMU

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Sep 4th, 3:33 PM

Marshall

Navy

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Sep 4th, 3:33 PM

Oklahoma (6)

Tulane

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Sep 4th, 3:33 PM

UTSA

Illinois

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Sep 4th, 3:33 PM

New Mexico State

San Diego State

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Sep 4th, 3:33 PM

Portland State

Hawaii

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Sep 4th, 3:33 PM

Indiana (12)

Iowa (16)

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Sep 4th, 3:33 PM

West Virginia

Maryland

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Sep 4th, 3:33 PM

Western Michigan

Michigan

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Sep 4th, 3:33 PM

Michigan State

Northwestern (10)

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Sep 4th, 3:33 PM

Lafayette

Air Force

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Sep 4th, 3:33 PM

Montana State

Wyoming

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Sep 4th, 3:33 PM

Oregon State

Purdue

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Sep 4th, 3:33 PM

Temple

Rutgers

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Sep 4th, 3:33 PM

Penn State

Wisconsin

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Sep 4th, 3:33 PM

South Dakota State

Colorado State

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Sep 4th, 6:00 PM

Gardner-Webb

Georgia Southern

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