Nov 7, 2020; Columbus, Ohio, USA; Ohio State Buckeyes quarterback Justin Fields (1) leads the team before the game against the Rutgers Scarlet Knights at Ohio Stadium. Mandatory Credit: Joseph Maiorana-USA TODAY Sports

NCAA Football Opening Lines Report

The opening lines for Week 12 in college football are loaded with large spreads, and there’s also three ranked matchups on the schedule.

Leading the ranked matchups is a Top 10 clash between No. 9 Indiana and No. 3 Ohio State. When Indiana vs Ohio State numbers were set for this game, the Buckeyes listed as a 19.5-point favorite. OSU has won 25 straight against Indiana, but don’t sleep on the Hoosiers here, as they are 7-1 ATS the last 8 times when dogs of 20 or more points.

(Indiana fans can bet the game at BetRivers Indiana)

Big Ten Opening Lines

Staying in the Big Ten, also on tap this week is No. 10 Wisconsin at No. 19 Northwestern. Wisconsin opened as a 7-point road favorite. As a road favorite Wisconsin is 4-2 straight up and ATS in their last six. (Wisconsin Northwestern Matchup Report)

The last ranked matchup in Week 12 is No. 14 Oklahoma State at No. 18 Oklahoma. Oklahoma State may be higher ranked, but they opened as an 8.5-point underdog. Oklahoma has won five straight against their state rivals with a 4-1 ATS record, and at home their 7-1 SU and 5-3 ATS in their last eight versus Oklahoma State.

The largest spread when the opening odds were set this week was in the North Alabama at BYU matchup. BYU opened as a whopping 46-point favorite. When facing a spread of 40 points or higher BYU is 5-0 SU and 3-1-1 ATS in their last five games.

There are five other games with a spread of 30 points or higher this week, starting with Clemson at Florida State. Clemson opened as a 32-point road favorite and when listed as a 30-plus point favorite on the road they’re 3-0 SU, but 0-3 ATS.

Also big road favorites this week is Florida when then visit Vanderbilt. They opened as a 30.5-point road favorite. Florida has only been favored by 30 points or more on the road once in the last 20 years, when they topped Kentucky 44-10 as a 30-point road favorite in 2001.

The other 30-plus point spread on the odds list this week include, Buffalo at Bowling Green (-30), Massachusetts at Florida Atlantic (-30), and tiny Abiliene Christian at Virginia (-35.5).

There are also seven other games with spreads of at least 20 points this week. A select few include Charlotte at Marshall (-21.5), Texas at Kansas (+28.5), Kentucky at Alabama (-29.5) and Mississippi at Georgia (-22.5).

Upcoming Games

Sep 25th, 2:30 PM

Washington State +13.5 -107

Utah -13.5 -107

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Sep 25th, 2:30 PM

Maine +22.5 -110

NIU -22.5 -110

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Sep 25th, 3:30 PM

Texas A&M (7) -7.5 -115

Arkansas (16) +7.5 -115

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Sep 25th, 3:30 PM

Louisville -3 -110

Florida State +3 -110

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Sep 25th, 3:30 PM

Clemson (9) -10.5 -107

NC State +10.5 -107

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Sep 25th, 3:30 PM

Wyoming -30 -107

UCONN +30 -107

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Sep 25th, 3:30 PM

Iowa State (14) -5.5 -107

Baylor +5.5 -107

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Sep 25th, 3:30 PM

UTSA +5 -107

Memphis -5 -107

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Sep 25th, 3:30 PM

Towson +23.5 -110

San Diego State -23.5 -110

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Sep 25th, 3:30 PM

Colorado State +23.5 -107

Iowa (5) -23.5 -107

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Sep 25th, 3:30 PM

Kent State +14.5 -107

Maryland -14.5 -107

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Sep 25th, 3:30 PM

Illinois +10 -107

Purdue -10 -107

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Sep 25th, 3:30 PM

Rutgers +18 -110

Michigan (19) -18 -110

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Sep 25th, 4:00 PM

Kansas +11.5 -110

Duke -11.5 -110

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Sep 25th, 4:00 PM

Georgia State +26 -107

Auburn (23) -26 -107

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Sep 25th, 5:00 PM

Arkansas State +13.5 -107

Tulsa -13.5 -107

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Sep 25th, 6:00 PM

UCLA (24) -3.5 -110

Stanford +3.5 -110

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Sep 25th, 6:00 PM

Louisiana-Lafayette -11.5 -110

Georgia Southern +11.5 -110

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Sep 25th, 6:00 PM

Buffalo -11.5 -107

Old Dominion +11.5 -107

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Sep 25th, 6:00 PM

Charleston Southern +27.5 -110

East Carolina -27.5 -110

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Sep 25th, 6:30 PM

Texas Southern +27.5 -110

Rice -27.5 -110

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Sep 25th, 7:00 PM

Tennessee +16.5 -107

Florida (11) -16.5 -107

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Sep 25th, 7:00 PM

Kentucky -4.5 -110

South Carolina +4.5 -110

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Sep 25th, 7:00 PM

North Texas +13 -107

LA Tech -13 -107

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Sep 25th, 7:00 PM

Kansas State (25) +7.5 -110

Oklahoma State -7.5 -110

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Sep 25th, 7:00 PM

Navy +21 -110

Houston -21 -110

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Sep 25th, 7:00 PM

Nebraska +3.5 -110

Michigan State (20) -3.5 -110

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Sep 25th, 7:30 PM

Southern Miss +42.5 -110

Alabama (1) -42.5 -110

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Sep 25th, 7:30 PM

West Virginia +19.5 -110

Oklahoma (4) -19.5 -110

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Sep 25th, 7:30 PM

North Carolina (21) -12.5 -107

Georgia Tech +12.5 -107

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Sep 25th, 7:30 PM

Akron +48.5 -110

Ohio State (10) -48.5 -110

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Sep 25th, 8:00 PM

Troy -23 -107

Louisiana-Monroe +23 -107

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Sep 25th, 8:00 PM

Indiana -9.5 -107

WKU +9.5 -107

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Sep 25th, 8:00 PM

UAB +4 -107

Tulane -4 -107

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Sep 25th, 8:00 PM

Florida Atlantic +4.5 -107

Air Force -4.5 -107

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Sep 25th, 8:00 PM

Hawaii -16.5 -107

New Mexico State +16.5 -107

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Sep 25th, 9:00 PM

New Mexico +3 -107

UTEP -3 -107

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Sep 25th, 9:30 PM

California +9.5 -107

Washington -9.5 -107

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Sep 25th, 10:15 PM

USF +23.5 -107

BYU (15) -23.5 -107

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Sep 25th, 10:30 PM

Arizona +27.5 -107

Oregon (3) -27.5 -107

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Sep 25th, 10:30 PM

Oregon State +10.5 -110

USC -10.5 -110

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Sep 25th, 10:30 PM

Colorado +13 -110

Arizona State -13 -110

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Sep 30th, 7:30 PM

Virginia

Miami-FL

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Oct 1st, 7:30 PM

Houston

Tulsa

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Oct 1st, 8:00 PM

Iowa (5)

Maryland

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Oct 1st, 9:00 PM

BYU (15)

Utah State

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Oct 2nd, 12:00 PM

Arkansas (16)

Georgia (2)

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Oct 2nd, 12:00 PM

Tennessee

Missouri

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Oct 2nd, 12:00 PM

Pittsburgh

Georgia Tech

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Oct 2nd, 12:00 PM

Western Michigan

Buffalo

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Oct 2nd, 12:00 PM

Texas 0 -110

TCU 0 -110

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Oct 2nd, 12:00 PM

Duke

North Carolina (21)

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Oct 2nd, 12:00 PM

Toledo

Massachusetts

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Oct 2nd, 12:00 PM

Charlotte

Illinois

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Oct 2nd, 12:00 PM

Memphis

Temple

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Oct 2nd, 12:00 PM

Minnesota

Purdue

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Oct 2nd, 12:00 PM

Michigan (19) +4.5 -107

Wisconsin (18) -4.5 -107

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Oct 2nd, 12:30 PM

Louisville

Wake Forest

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Oct 2nd, 2:00 PM

Appalachian State

Georgia State

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Oct 2nd, 2:00 PM

USC

Colorado

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Oct 2nd, 2:30 PM

Louisiana-Monroe

Coastal Carolina (17)

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Oct 2nd, 2:30 PM

Eastern Michigan

NIU

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Oct 2nd, 2:30 PM

Cincinnati (8) +1.5 -107

Notre Dame (12) -1.5 -107

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Oct 2nd, 3:30 PM

Troy

South Carolina

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Oct 2nd, 3:30 PM

Ole Miss (13) +16.5 -110

Alabama (1) -16.5 -110

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Oct 2nd, 3:30 PM

Oregon (3)

Stanford

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Oct 2nd, 3:30 PM

Florida International (FIU)

Florida Atlantic

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Oct 2nd, 3:30 PM

Syracuse

Florida State

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Oct 2nd, 3:30 PM

Bowling Green

Kent State

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Oct 2nd, 3:30 PM

Central Michigan

Miami-OH

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Oct 2nd, 3:30 PM

Ohio

Akron

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Oct 2nd, 3:30 PM

Texas Tech

West Virginia

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Oct 2nd, 3:30 PM

Oklahoma (4)

Kansas State (25)

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Oct 2nd, 3:30 PM

UCF

Navy

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Oct 2nd, 3:30 PM

Nevada

Boise State

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Oct 2nd, 3:30 PM

Tulane

East Carolina

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Oct 2nd, 3:30 PM

Ohio State (10)

Rutgers

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Oct 2nd, 3:33 PM

Florida (11)

Kentucky

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Oct 2nd, 3:33 PM

Mississippi State

Texas A&M (7)

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Oct 2nd, 4:00 PM

Arkansas State

Georgia Southern

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Oct 2nd, 4:00 PM

USF

SMU

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Oct 2nd, 5:00 PM

Army

Ball State

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Oct 2nd, 5:30 PM

Washington State

California

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Oct 2nd, 6:00 PM

UNLV

UTSA

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Oct 2nd, 6:00 PM

LA Tech

NC State

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Oct 2nd, 6:30 PM

Southern Miss

Rice

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Oct 2nd, 6:30 PM

Air Force

New Mexico

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Oct 2nd, 7:00 PM

Kansas

Iowa State (14)

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Oct 2nd, 7:00 PM

Baylor

Oklahoma State

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Oct 2nd, 7:00 PM

Marshall

Middle Tennessee

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Oct 2nd, 7:00 PM

Liberty

UAB

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Oct 2nd, 7:30 PM

Boston College

Clemson (9)

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Oct 2nd, 7:30 PM

UCONN

Vanderbilt

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Oct 2nd, 7:30 PM

WKU

Michigan State (20)

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Oct 2nd, 7:30 PM

Northwestern

Nebraska

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Oct 2nd, 7:30 PM

Indiana

Penn State (6)

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Oct 2nd, 8:00 PM

Louisiana-Lafayette

South Alabama

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Oct 2nd, 9:00 PM

Washington

Oregon State

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Oct 2nd, 9:00 PM

Auburn (23) +3.5 -110

LSU -3.5 -110

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Oct 2nd, 9:00 PM

Old Dominion

UTEP

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Oct 2nd, 10:30 PM

Arizona State +3.5 -107

UCLA (24) -3.5 -107

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Oct 2nd, 10:30 PM

New Mexico State

San Jose State

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Oct 2nd, 11:00 PM

Fresno State (22)

Hawaii

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