Nov 7, 2020; Columbus, Ohio, USA; Ohio State Buckeyes quarterback Justin Fields (1) leads the team before the game against the Rutgers Scarlet Knights at Ohio Stadium. Mandatory Credit: Joseph Maiorana-USA TODAY Sports

NCAA Football Opening Lines Report

The opening lines for Week 12 in college football are loaded with large spreads, and there’s also three ranked matchups on the schedule.

Leading the ranked matchups is a Top 10 clash between No. 9 Indiana and No. 3 Ohio State. When Indiana vs Ohio State numbers were set for this game, the Buckeyes listed as a 19.5-point favorite. OSU has won 25 straight against Indiana, but don’t sleep on the Hoosiers here, as they are 7-1 ATS the last 8 times when dogs of 20 or more points.

(Indiana fans can bet the game at BetRivers Indiana)

Big Ten Opening Lines

Staying in the Big Ten, also on tap this week is No. 10 Wisconsin at No. 19 Northwestern. Wisconsin opened as a 7-point road favorite. As a road favorite Wisconsin is 4-2 straight up and ATS in their last six. (Wisconsin Northwestern Matchup Report)

The last ranked matchup in Week 12 is No. 14 Oklahoma State at No. 18 Oklahoma. Oklahoma State may be higher ranked, but they opened as an 8.5-point underdog. Oklahoma has won five straight against their state rivals with a 4-1 ATS record, and at home their 7-1 SU and 5-3 ATS in their last eight versus Oklahoma State.

The largest spread when the opening odds were set this week was in the North Alabama at BYU matchup. BYU opened as a whopping 46-point favorite. When facing a spread of 40 points or higher BYU is 5-0 SU and 3-1-1 ATS in their last five games.

There are five other games with a spread of 30 points or higher this week, starting with Clemson at Florida State. Clemson opened as a 32-point road favorite and when listed as a 30-plus point favorite on the road they’re 3-0 SU, but 0-3 ATS.

Also big road favorites this week is Florida when then visit Vanderbilt. They opened as a 30.5-point road favorite. Florida has only been favored by 30 points or more on the road once in the last 20 years, when they topped Kentucky 44-10 as a 30-point road favorite in 2001.

The other 30-plus point spread on the odds list this week include, Buffalo at Bowling Green (-30), Massachusetts at Florida Atlantic (-30), and tiny Abiliene Christian at Virginia (-35.5).

There are also seven other games with spreads of at least 20 points this week. A select few include Charlotte at Marshall (-21.5), Texas at Kansas (+28.5), Kentucky at Alabama (-29.5) and Mississippi at Georgia (-22.5).

Upcoming Games

Dec 1st, 10:30 AM

WKU +1.5 -110

Charlotte -1.5 -110

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Dec 3rd, 9:30 PM

Air Force -10.5 -110

Utah State +10.5 -110

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Dec 4th, 7:30 PM

Louisiana-Lafayette (20) +2.5 -115

Appalachian State -2.5 -115

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Dec 4th, 9:30 PM

Boise State -27 -110

UNLV +27 -110

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Dec 5th, 12:00 PM

Texas A&M (5) -6.5 -110

Auburn +6.5 -110

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Dec 5th, 12:00 PM

Texas -9.5 -110

Kansas State +9.5 -110

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Dec 5th, 12:00 PM

Oklahoma State (19) -2.5 -110

TCU +2.5 -110

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Dec 5th, 12:00 PM

Kansas +27 -110

Texas Tech -27 -110

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Dec 5th, 12:00 PM

Northwestern (16) -10 -110

Minnesota +10 -110

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Dec 5th, 12:00 PM

Nebraska +2 -110

Purdue -2 -110

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Dec 5th, 12:00 PM

Ohio State (3) -22.5 -110

Michigan State +22.5 -110

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Dec 5th, 12:00 PM

Penn State -10.5 -110

Rutgers +10.5 -110

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Dec 5th, 12:00 PM

Memphis +1.5 -110

Tulane -1.5 -110

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Dec 5th, 12:00 PM

Kent State -3.5 -110

Miami-OH +3.5 -110

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Dec 5th, 12:00 PM

Toledo -10 -110

NIU +10 -110

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Dec 5th, 12:00 PM

Western Carolina +48.5 -110

North Carolina -48.5 -110

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Dec 5th, 12:00 PM

Cincinnati (7) -3.5 -110

Tulsa (22) +3.5 -110

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Dec 5th, 12:00 PM

Arkansas +3 -110

Missouri -3 -110

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Dec 5th, 2:00 PM

Eastern Michigan +13.5 -115

Western Michigan -13.5 -115

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Dec 5th, 2:00 PM

Bowling Green +2.5 -110

Akron -2.5 -110

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Dec 5th, 2:00 PM

Troy -5 -110

South Alabama +5 -110

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Dec 5th, 2:00 PM

Liberty (25) +7 -110

Coastal Carolina (14) -7 -110

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Dec 5th, 2:30 PM

Syracuse +33.5 -110

Notre Dame (2) -33.5 -110

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Dec 5th, 2:33 PM

Fresno State +7 -110

Nevada -7 -110

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Dec 5th, 3:00 PM

Louisiana-Monroe +21 -110

Arkansas State -21 -110

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Dec 5th, 3:30 PM

Florida (6) -17 -110

Tennessee +17 -110

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Dec 5th, 3:30 PM

West Virginia +7 -105

Iowa State (12) -7 -105

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Dec 5th, 3:30 PM

Indiana (10) +13 -110

Wisconsin (18) -13 -110

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Dec 5th, 3:30 PM

Iowa (24) -13 -110

Illinois +13 -110

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Dec 5th, 3:30 PM

Maryland +5 -115

Michigan -5 -115

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Dec 5th, 3:30 PM

Buffalo -11.5 -110

Ohio +11.5 -110

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Dec 5th, 3:30 PM

Boston College +6 -110

Virginia -6 -110

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Dec 5th, 4:00 PM

Vanderbilt +35.5 -110

Georgia (11) -35.5 -110

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Dec 5th, 4:00 PM

Stanford +11 -110

Washington (23) -11 -110

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Dec 5th, 4:00 PM

Hawaii +6.5 -105

San Jose State -6.5 -105

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Dec 5th, 4:00 PM

Georgia Tech +7 -110

NC State -7 -110

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Dec 5th, 5:30 PM

Ball State +1.5 -110

Central Michigan -1.5 -110

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Dec 5th, 6:00 PM

Florida Atlantic +1 -110

Georgia Southern -1 -110

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Dec 5th, 7:00 PM

Colorado -4 -110

Arizona +4 -110

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Dec 5th, 7:00 PM

Oregon (21) -9.5 -110

California +9.5 -110

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Dec 5th, 7:00 PM

Colorado State +8.5 -110

San Diego State -8.5 -110

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Dec 5th, 7:30 PM

South Carolina +11.5 -110

Kentucky -11.5 -110

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Dec 5th, 7:30 PM

Clemson (4) -21.5 -110

Virginia Tech +21.5 -110

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Dec 5th, 8:00 PM

Alabama (1) -28.5 -110

LSU +28.5 -110

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Dec 5th, 8:00 PM

Baylor +21.5 -115

Oklahoma (13) -21.5 -115

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Dec 5th, 8:00 PM

Miami-FL (9) -16.5 -107

Duke +16.5 -107

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Dec 5th, 10:30 PM

UCLA +4 -110

Arizona State -4 -110

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Dec 5th, 10:30 PM

Wyoming -16.5 -110

New Mexico +16.5 -110

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Dec 5th, 10:30 PM

Oregon State +9.5 -110

Utah -9.5 -110

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Dec 6th, 2:30 PM

UAB

Middle Tennessee

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Dec 6th, 9:00 PM

Washington State +14 -110

USC (17) -14 -110

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