Nov 25, 2017; Auburn, AL, USA; Alabama Crimson Tide head coach Nick Saban reacts during the fourth quarter against the Auburn Tigers at Jordan-Hare Stadium. Mandatory Credit: John David Mercer-USA TODAY Sports

SEC football betting odds, opening lines

SEC football betting begins with Week 4 opening odds and the promise of plenty of new wagering interest as these marquee programs kick off.

The game with the largest spread on the opening odds list is an SEC matchup. Texas A&M begins their season as a 30-point favorite against Vanderbilt. When favored by 30 points or more Texas A&M has won 28 straight but owns a 15-13 record ATS. Think back to last season, Vandy was a 21.5-point home underdog and upset Missouri.

[ Check out college football odds on every game here at NFP ]

Alabama vs Missouri odds

Speaking of Mizzou, Alabama kicks off their season as 28-point road favorites against the Missouri Tigers. Alabama has won their last three against Missouri both SU and ATS and the Tigers will have many players on the sidelines for Covid-19 precautions.

It’s been eight years since Mizzou laid so many point at home and that was 2012 at home to, you guessed it, Alabama and they got hammered 42-10. Nick Saban wants another title and Bama opened the season as SEC faves.

Other SEC road favorites this weekend include Florida at Ole’ Miss as a 10-point favorite, Tennessee at South Carolina as a 2.5-point favorite, and Georgia at Arkansas as a 24.5-point favorite. Georgia has been a sold pick as a road favorite with five straight wins both SU and ATS.

Rounding out this weekend’s SEC matchups is Auburn hosting Kentucky as a 13.5-point favorite and LSU at home to Mississippi State as a 19.5-point favorite. LSU, the reigning national champions, have won 16 straight at home with a 11-3-2 ATS record.

More NCAA opening odds

Outside of the SEC there are a pair of Top 25 matchups on the schedule this weekend. No. 14 Cincinnati hosts No. 22 Army as a 12.5-point favorite. The other Top 25 matchup is No. 21 Pittsburgh hosting No. 24 Louisville as a 2.5-point favorite. Pittsburgh is 5-1 SU in their last six versus Pittsburgh and 6-1 ATS in their last seven matchups.

A few other large spreads on the opening odds include Oklahoma as a 27-point favorite at home against Kansas State, Notre Dame at Wake Forest as a 21.5-point favorite, and Central Florida at East Carolina as a 24.5-point favorite.

Last season Oklahoma was a 23.5-point road favorite versus Kansas State and they lost in a 48-41 upset.

In their last 10 games when favored by just over three touchdowns, Notre Dame is only 4-5-1 ATS.

In their last 10 games as a road favorite Central Florida is 8-2 SU and 6-4 ATS. Their opponents, East Carolina has lost six straight as a home underdog with a 1-5 ATS record.