Dec 5, 2020; Champaign, Illinois, USA; Iowa Hawkeyes fullback Monte Pottebaum (38) runs the ball against Illinois Fighting Illini linebacker Khalan Tolson (45) during the first half at Memorial Stadium. Mandatory Credit: Patrick Gorski-USA TODAY Sports

Week 15 College Football Opening Lines

Week 15 in college football delivers three Top 25 matchups and the usual batch of big spreads for bettors to debate over.

Get the latest college football opening lines and odds updates during the week, along with matchup reports of every game.

Starting off the Top 25 matchups is No. 7 Cincinnati at No. 18 Tulsa. The opening odds for this one pegged Cincinnati as a 3.5-point road favorite. Cincinnati has won nine straight with a 6-3 record against the spread and as a road favorite they’re 3-5 ATS in their last eight.

The next Top 25 matchup is No. 9 North Carolina at No. 20 Miami. When the odds were first set for this matchup Miami was listed as a 4-point favorite. North Carolina is 1-4 ATS in their last five games and they’re 2-11 SU in their last 13 games as an underdog.

The last ranked matchup is in the Big Ten where No. 19 Iowa hosts No. 25 Wisconsin. Iowa may be at home but they opened as a 2.5-point underdog. Iowa has won five straight at 4-1 ATS, while Wisconsin is 3-3 SU and ATS in their last six road games.

The largest spread on the board when the odds were set this week was in the Akron at Buffalo matchup. The opening odds listed Buffalo as a 33.5-point favorite. In their last four games when favored by 30 points of more Buffalo is 0-4 ATS.

There are five games that opened with a spread of at least 20 points this week, starting with Texas at Kansas. Texas opened as a 28.5-point road favorite. When favored by 20 points or more on the road, Texas is 21-1 SU and 11-11 ATS in their last 22 games.

Also opening as a road favorite with a spread of more than 20 points this week was Miami (Ohio) at Bowling Green. Miami opened as a 21.5-point road favorite. As a road favorite Miami is 6-2 ATS in their last eight. Bowling Green has been the underdog in all six games this season, posting a 1-5 record ATS.

The other games with spreads of 20 points or more this week include Incarnate Word at Arkansas State (-21.5), Louisiana Tech at TCU (-21.5), and UNLV at Hawaii (-21.5).

One other game that caught our attention this week when the odds were posted drew a rare pick’em. That was in the California at Washington State matchup. That matchup should be watched this week to see which way the line moves when the money starts coming in

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Upcoming Games

Aug 26th, 2:30 PM

Navy +17 -111

Notre Dame (18) -17 -111

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Aug 26th, 5:30 PM

UTEP +2.5 -110

Jacksonville State -2.5 -110

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Aug 26th, 7:00 PM

Massachusetts +10 -110

New Mexico State -10 -110

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Aug 26th, 7:00 PM

Ohio +4.5 -110

San Diego State -4.5 -110

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Aug 26th, 7:30 PM

Hawaii +17.5 -110

Vanderbilt -17.5 -110

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Aug 26th, 8:00 PM

San Jose State +30 -110

USC (12) -30 -110

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Aug 26th, 9:00 PM

Florida International (FIU) +10 -105

LA Tech -10 -105

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Aug 31st, 7:00 PM

Elon

Wake Forest

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Aug 31st, 7:00 PM

Kent State +32 -110

UCF -32 -110

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Aug 31st, 7:00 PM

Rhode Island

Georgia State

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Aug 31st, 7:00 PM

St. Francis-PA

Western Michigan

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Aug 31st, 7:30 PM

NC State -16 -110

UCONN +16 -110

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Aug 31st, 8:00 PM

Missouri State

Kansas

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Aug 31st, 8:00 PM

Florida +8 -110

Utah (10) -8 -110

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Aug 31st, 8:00 PM

Nebraska +8 -111

Minnesota -8 -111

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Aug 31st, 8:00 PM

North Carolina A&T

UAB

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Aug 31st, 8:00 PM

South Dakota

Missouri

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Aug 31st, 8:00 PM

Arkansas-Pine Bluff

Tulsa

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Aug 31st, 10:00 PM

Southern Utah

Arizona State

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Sep 1st, 6:30 PM

Howard

Eastern Michigan

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Sep 1st, 7:00 PM

Miami-OH +15.5 -111

Miami-FL -15.5 -111

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Sep 1st, 7:00 PM

Central Michigan +14 -110

Michigan State -14 -110

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Sep 1st, 7:30 PM

Louisville -9.5 -110

Georgia Tech +9.5 -110

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Sep 1st, 11:00 PM

Stanford -10 -110

Hawaii +10 -110

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Sep 2nd, 12:00 PM

NIU +10 -110

Boston College -10 -110

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Sep 2nd, 12:00 PM

Colorado +16.5 -111

TCU (2) -16.5 -111

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Sep 2nd, 12:00 PM

Arkansas State +33 -110

Oklahoma -33 -110

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Sep 2nd, 12:00 PM

Ball State +27 -110

Kentucky -27 -110

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Sep 2nd, 12:00 PM

LA Tech +14.5 -110

SMU -14.5 -110

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Sep 2nd, 12:00 PM

Bowling Green +11.5 -110

Liberty -11.5 -110

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Sep 2nd, 12:00 PM

Utah State +21 -110

Iowa -21 -110

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Sep 2nd, 12:00 PM

East Carolina +36.5 -110

Michigan (3) -36.5 -110

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Sep 2nd, 12:00 PM

Fresno State (24) +6 -110

Purdue -6 -110

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Sep 2nd, 1:00 PM

Virginia +28.5 -110

Tennessee (6) -28.5 -110

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Sep 2nd, 2:00 PM

Northern Iowa

Iowa State

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Sep 2nd, 2:00 PM

Mercer

Ole Miss

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Sep 2nd, 2:00 PM

East Tennessee State

Jacksonville State

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Sep 2nd, 2:00 PM

Akron +10.5 -110

Temple -10.5 -110

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Sep 2nd, 2:00 PM

LIU

Ohio

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Sep 2nd, 3:00 PM

Portland State

Oregon (15)

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Sep 2nd, 3:30 PM

Wofford

Pittsburgh (22)

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Sep 2nd, 3:30 PM

Rice +35.5 -110

Texas (25) -35.5 -110

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Sep 2nd, 3:30 PM

Eastern Kentucky

Cincinnati

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Sep 2nd, 3:30 PM

Boise State +16 -110

Washington (8) -16 -110

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Sep 2nd, 3:30 PM

Massachusetts +40 -110

Auburn -40 -110

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Sep 2nd, 3:30 PM

USF +13 -110

WKU -13 -110

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Sep 2nd, 3:30 PM

Ohio State (4) -27.5 -110

Indiana +27.5 -110

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Sep 2nd, 3:30 PM

Towson

Maryland

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Sep 2nd, 3:30 PM

Buffalo +24 -110

Wisconsin -24 -110

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Sep 2nd, 3:30 PM

Tennessee State

Notre Dame (18)

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Sep 2nd, 3:30 PM

Gardner-Webb

Appalachian State

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Sep 2nd, 3:33 PM

Bryant

UNLV

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Sep 2nd, 3:33 PM

Robert Morris

Air Force

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Sep 2nd, 4:00 PM

Colgate

Syracuse

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Sep 2nd, 4:00 PM

California -8 -110

North Texas +8 -110

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Sep 2nd, 4:00 PM

Western Carolina

Arkansas

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Sep 2nd, 4:00 PM

Southeastern Louisiana

Mississippi State (20)

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Sep 2nd, 6:00 PM

Tennessee-Martin

Georgia (1)

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Sep 2nd, 6:00 PM

South Carolina State

Charlotte

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Sep 2nd, 6:00 PM

Monmouth-New Jersey

Florida Atlantic

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Sep 2nd, 6:00 PM

Bucknell

James Madison

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Sep 2nd, 6:00 PM

The Citadel

Georgia Southern

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Sep 2nd, 6:00 PM

Albany-NY

Marshall

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Sep 2nd, 6:30 PM

Nevada +35.5 -110

USC (12) -35.5 -110

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Sep 2nd, 6:30 PM

Maine

Florida International (FIU)

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Sep 2nd, 7:00 PM

Southeast Missouri State

Kansas State (14)

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Sep 2nd, 7:00 PM

Central Arkansas

Oklahoma State

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Sep 2nd, 7:00 PM

Texas State +24.5 -110

Baylor -24.5 -110

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Sep 2nd, 7:00 PM

UTSA +2.5 -110

Houston -2.5 -110

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Sep 2nd, 7:00 PM

Washington State -17 -110

Colorado State +17 -110

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Sep 2nd, 7:00 PM

Alabama A&M

Vanderbilt

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Sep 2nd, 7:00 PM

New Mexico +38 -110

Texas A&M -38 -110

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Sep 2nd, 7:00 PM

Army -8 -110

Louisiana-Monroe +8 -110

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Sep 2nd, 7:00 PM

Bethune-Cookman

Memphis

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Sep 2nd, 7:00 PM

Stephen F. Austin

Troy (19)

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Sep 2nd, 7:00 PM

Alcorn State

Southern Miss

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Sep 2nd, 7:30 PM

North Carolina -1.5 -110

South Carolina (23) +1.5 -110

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Sep 2nd, 7:30 PM

West Virginia +18.5 -111

Penn State (7) -18.5 -111

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Sep 2nd, 7:30 PM

Texas Tech -14 -110

Wyoming +14 -110

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Sep 2nd, 7:30 PM

Middle Tennessee +37 -110

Alabama (5) -37 -110

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Sep 2nd, 7:30 PM

Toledo +11.5 -110

Illinois -11.5 -110

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Sep 2nd, 7:30 PM

Northwestern State

Louisiana-Lafayette

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Sep 2nd, 8:00 PM

Old Dominion +14.5 -110

Virginia Tech -14.5 -110

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Sep 2nd, 8:00 PM

South Alabama +7 -110

Tulane (9) -7 -110

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Sep 2nd, 9:00 PM

Western Illinois

New Mexico State

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Sep 2nd, 9:00 PM

Incarnate Word

UTEP

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Sep 2nd, 10:00 PM

Northern Arizona

Arizona

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Sep 2nd, 10:15 PM

Sam Houston State +23.5 -105

BYU -23.5 -105

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Sep 2nd, 10:30 PM

Coastal Carolina +14.5 -105

UCLA (21) -14.5 -105

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Sep 2nd, 10:30 PM

Idaho State

San Diego State

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