Dec 5, 2020; Champaign, Illinois, USA; Iowa Hawkeyes fullback Monte Pottebaum (38) runs the ball against Illinois Fighting Illini linebacker Khalan Tolson (45) during the first half at Memorial Stadium. Mandatory Credit: Patrick Gorski-USA TODAY Sports

Week 15 College Football Opening Lines

Week 15 in college football delivers three Top 25 matchups and the usual batch of big spreads for bettors to debate over.

Get the latest college football opening lines and odds updates during the week, along with matchup reports of every game.

Starting off the Top 25 matchups is No. 7 Cincinnati at No. 18 Tulsa. The opening odds for this one pegged Cincinnati as a 3.5-point road favorite. Cincinnati has won nine straight with a 6-3 record against the spread and as a road favorite they’re 3-5 ATS in their last eight.

The next Top 25 matchup is No. 9 North Carolina at No. 20 Miami. When the odds were first set for this matchup Miami was listed as a 4-point favorite. North Carolina is 1-4 ATS in their last five games and they’re 2-11 SU in their last 13 games as an underdog.

The last ranked matchup is in the Big Ten where No. 19 Iowa hosts No. 25 Wisconsin. Iowa may be at home but they opened as a 2.5-point underdog. Iowa has won five straight at 4-1 ATS, while Wisconsin is 3-3 SU and ATS in their last six road games.

The largest spread on the board when the odds were set this week was in the Akron at Buffalo matchup. The opening odds listed Buffalo as a 33.5-point favorite. In their last four games when favored by 30 points of more Buffalo is 0-4 ATS.

There are five games that opened with a spread of at least 20 points this week, starting with Texas at Kansas. Texas opened as a 28.5-point road favorite. When favored by 20 points or more on the road, Texas is 21-1 SU and 11-11 ATS in their last 22 games.

Also opening as a road favorite with a spread of more than 20 points this week was Miami (Ohio) at Bowling Green. Miami opened as a 21.5-point road favorite. As a road favorite Miami is 6-2 ATS in their last eight. Bowling Green has been the underdog in all six games this season, posting a 1-5 record ATS.

The other games with spreads of 20 points or more this week include Incarnate Word at Arkansas State (-21.5), Louisiana Tech at TCU (-21.5), and UNLV at Hawaii (-21.5).

One other game that caught our attention this week when the odds were posted drew a rare pick’em. That was in the California at Washington State matchup. That matchup should be watched this week to see which way the line moves when the money starts coming in

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Upcoming Games

Aug 28th, 1:00 PM

Nebraska -7 -110

Illinois +7 -110

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Aug 28th, 2:00 PM

UCONN +27.5 -110

Fresno State -27.5 -110

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Aug 28th, 3:30 PM

Hawaii +17 -110

UCLA -17 -110

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Aug 28th, 9:30 PM

UTEP -7.5 -110

New Mexico State +7.5 -110

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Aug 28th, 10:00 PM

Southern Utah

San Jose State (24)

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Sep 1st, 7:30 PM

UAB

Jacksonville State

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Sep 2nd, 6:30 PM

Temple +13.5 -110

Rutgers -13.5 -110

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Sep 2nd, 7:00 PM

LIU

Florida International (FIU)

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Sep 2nd, 7:00 PM

Western Illinois

Ball State (23)

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Sep 2nd, 7:00 PM

The Citadel

Coastal Carolina (14)

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Sep 2nd, 7:00 PM

Wagner

Buffalo (25)

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Sep 2nd, 7:00 PM

Boise State +4 -110

UCF -4 -110

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Sep 2nd, 7:30 PM

Weber State

Utah

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Sep 2nd, 7:30 PM

USF +18 -110

NC State -18 -110

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Sep 2nd, 7:30 PM

UC Davis

Tulsa

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Sep 2nd, 7:30 PM

East Carolina +12 -110

Appalachian State -12 -110

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Sep 2nd, 8:00 PM

Ohio State (2) -13.5 -110

Minnesota +13.5 -110

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Sep 2nd, 8:00 PM

Houston Baptist

New Mexico

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Sep 2nd, 8:00 PM

Bowling Green +33 -110

Tennessee -33 -110

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Sep 2nd, 8:00 PM

Tennessee-Martin

WKU

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Sep 2nd, 10:00 PM

Eastern Washington

UNLV

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Sep 2nd, 10:30 PM

Southern Utah

Arizona State

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Sep 3rd, 6:00 PM

North Carolina (18) -5.5 -110

Virginia Tech +5.5 -110

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Sep 3rd, 7:00 PM

St. Francis-PA

Eastern Michigan

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Sep 3rd, 7:00 PM

Old Dominion +32.5 -110

Wake Forest -32.5 -110

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Sep 3rd, 7:00 PM

Duke -7 -110

Charlotte +7 -110

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Sep 3rd, 8:00 PM

South Dakota

Kansas

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Sep 3rd, 9:00 PM

Northern Colorado

Colorado

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Sep 3rd, 9:00 PM

Michigan State +4 -110

Northwestern (10) -4 -110

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Sep 3rd, 9:00 PM

South Dakota State

Colorado State

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Sep 4th, 12:00 PM

Colgate

Boston College

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Sep 4th, 12:00 PM

Louisiana-Monroe +29.5 -110

Kentucky -29.5 -110

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Sep 4th, 12:00 PM

Army +3 -105

Georgia State -3 -105

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Sep 4th, 12:00 PM

Stanford -1.5 -110

Kansas State +1.5 -110

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Sep 4th, 12:00 PM

Holy Cross

UCONN

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Sep 4th, 12:00 PM

Oklahoma (6) -24.5 -110

Tulane +24.5 -110

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Sep 4th, 12:00 PM

Western Michigan +17.5 -110

Michigan -17.5 -110

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Sep 4th, 12:00 PM

Penn State +4.5 -110

Wisconsin -4.5 -110

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Sep 4th, 12:00 PM

Fordham

Nebraska

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Sep 4th, 2:00 PM

Fresno State +22 -110

Oregon -22 -110

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Sep 4th, 2:00 PM

Rice +20 -110

Arkansas -20 -110

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Sep 4th, 2:00 PM

Lafayette

Air Force

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Sep 4th, 3:30 PM

Alabama (1) -18 -110

Miami-FL (22) +18 -110

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Sep 4th, 3:30 PM

Miami-OH +23 -110

Cincinnati (8) -23 -110

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Sep 4th, 3:30 PM

Marshall -2.5 -110

Navy +2.5 -110

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Sep 4th, 3:30 PM

Indiana (12) +4.5 -110

Iowa (16) -4.5 -110

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Sep 4th, 3:30 PM

West Virginia -3.5 -110

Maryland +3.5 -110

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Sep 4th, 4:00 PM

Central Michigan +13 -110

Missouri -13 -110

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Sep 4th, 4:00 PM

LA Tech +26.5 -110

Mississippi State -26.5 -110

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Sep 4th, 4:00 PM

Massachusetts +37.5 -110

Pittsburgh -37.5 -110

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Sep 4th, 4:00 PM

Montana State

Wyoming

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Sep 4th, 4:30 PM

Northern Iowa

Iowa State (9)

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Sep 4th, 4:30 PM

Louisiana-Lafayette (15) +9.5 -110

Texas (19) -9.5 -110

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Sep 4th, 5:00 PM

San Jose State (24) +16 -110

USC (21) -16 -110

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Sep 4th, 6:00 PM

Campbell

Liberty (17)

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Sep 4th, 6:00 PM

Gardner-Webb

Georgia Southern

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Sep 4th, 7:00 PM

Eastern Illinois

South Carolina

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Sep 4th, 7:00 PM

Akron +36.5 -110

Auburn -36.5 -110

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Sep 4th, 7:00 PM

Southern University

Troy

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Sep 4th, 7:00 PM

Missouri State

Oklahoma State (20)

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Sep 4th, 7:00 PM

Monmouth-New Jersey

Middle Tennessee

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Sep 4th, 7:00 PM

Baylor -13.5 -110

Texas State +13.5 -110

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Sep 4th, 7:00 PM

Syracuse -1 -110

Ohio +1 -110

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Sep 4th, 7:00 PM

Central Arkansas

Arkansas State

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Sep 4th, 7:00 PM

Norfolk State

Toledo

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Sep 4th, 7:00 PM

Texas Tech -2.5 -110

Houston +2.5 -110

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Sep 4th, 7:00 PM

Nicholls State

Memphis

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Sep 4th, 7:00 PM

Abilene Christian

SMU

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Sep 4th, 7:00 PM

Oregon State +7 -110

Purdue -7 -110

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Sep 4th, 7:30 PM

Georgia (7) +3.5 -110

Clemson (3) -3.5 -110

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Sep 4th, 7:30 PM

Florida Atlantic +25 -110

Florida (13) -25 -110

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Sep 4th, 7:30 PM

NIU +17.5 -110

Georgia Tech -17.5 -110

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Sep 4th, 7:30 PM

Northwestern State

North Texas

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Sep 4th, 7:30 PM

William & Mary

Virginia

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Sep 4th, 7:30 PM

UTSA +7 +100

Illinois -7 +100

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Sep 4th, 8:00 PM

Montana

Washington

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Sep 4th, 8:00 PM

East Tennessee State

Vanderbilt

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Sep 4th, 8:00 PM

Kent State +30 -110

Texas A&M (4) -30 -110

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Sep 4th, 8:00 PM

Southern Miss -1.5 -110

South Alabama +1.5 -110

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Sep 4th, 8:00 PM

Duquesne

TCU

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Sep 4th, 8:30 PM

LSU -4.5 -110

UCLA +4.5 -110

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Sep 4th, 9:00 PM

Bethune-Cookman

UTEP

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Sep 4th, 10:30 PM

Nevada +3.5 -110

California -3.5 -110

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Sep 4th, 10:30 PM

BYU (11) -11.5 -110

Arizona +11.5 -110

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Sep 4th, 10:30 PM

New Mexico State +30 -110

San Diego State -30 -110

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Sep 4th, 11:00 PM

Utah State +16.5 -110

Washington State -16.5 -110

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