Arizona Cardinals vs San Francisco 49ers Betting Report
September 21, 2025, 4:25 pm |
Levi's Stadium
Arizona
Cardinals 2-0
San Francisco
49ers 2-0
|
Sep 21st, 4:25 PM |
FanDuel | NFP Opening | BetRivers | SugarHouse | NFP Consensus |
|---|---|---|---|---|---|
|
Arizona San Francisco Spread
|
+1.5
-1.5
-110
-110
|
+3.5
-3.5
-110
-110
|
+1.5
-1.5
-111
-111
|
+1.5
-1.5
-111
-111
|
+1.5
-1.5
-110
-110
|
|
Total
|
44
o -110
u -110
|
47.5
o -115
u -105
|
44.5
o -111
u -111
|
44.5
o -111
u -111
|
44.5
o -110
u -110
|
|
Moneyline
|
+104
-124
|
+150
-180
|
+105
-125
|
+105
-125
|
+105
-125
|
Recent Form
| Name | Record | ATS | Offense | Defense | ATS Home | ATS Away | OU Record | OU Home | OU Away |
|---|---|---|---|---|---|---|---|---|---|
| Arizona | 2-0 | 1-1 | 23.5 | 17.5 | 0-1 | 1-0 | 1-1 | 1-0 | 0-1 |
| San Francisco | 2-0 | 2-0 | 21.5 | 17 | 0-0 | 2-0 | 1-1 | 0-0 | 1-1 |
Football Betting Trends
| San Francisco 49ers |
|---|
| San Francisco is 3-8 ATS in its last 11 games |
| San Francisco is 3-7 SU in its last 10 games |
| The total has gone OVER in 4 of San Francisco's last 5 games |
| San Francisco is 4-2 ATS in its last 6 games when playing Arizona |
| San Francisco is 5-9-1 ATS in its last 15 games when playing Arizona |
| San Francisco is 4-2 SU in its last 6 games when playing Arizona |
| The total has gone OVER in 6 of San Francisco's last 7 games when playing Arizona |
| San Francisco is 2-6-1 ATS in its last 9 games when playing at home against Arizona |
| San Francisco is 3-7 SU in its last 10 games when playing at home against Arizona |
| The total has gone OVER in 5 of San Francisco's last 7 games when playing at home against Arizona |
| San Francisco is 4-12 ATS in its last 16 games at home |
| San Francisco is 17-8 SU in its last 25 games at home |
| San Francisco is 2-5 SU in its last 7 games at home |
| Arizona Cardinals |
|---|
| Arizona is 9-4 ATS in its last 13 games |
| Arizona is 4-2 SU in its last 6 games |
| The total has gone OVER in 5 of Arizona's last 7 games |
| Arizona is 7-3 ATS in its last 10 games on the road |
| Arizona is 1-4 SU in its last 5 games on the road |
| The total has gone UNDER in 4 of Arizona's last 5 games on the road |
| Arizona is 2-4 ATS in its last 6 games when playing San Francisco |
| Arizona is 2-4 SU in its last 6 games when playing San Francisco |
| The total has gone OVER in 6 of Arizona's last 7 games when playing San Francisco |
| Arizona is 6-2-1 ATS in its last 9 games when playing on the road against San Francisco |
| Arizona is 7-3 SU in its last 10 games when playing on the road against San Francisco |
| The total has gone OVER in 5 of Arizona's last 7 games when playing on the road against San Francisco |
Power Stats
Yards Per Point
| Name | Offense | Defense | Differential |
|---|---|---|---|
| ARI | 13.37 | 20.04 | -6.67 |
| SF | 18.35 | 16.27 | 2.08 |
Yards Per Pass
| Name | Offense | Defense | Differential |
|---|---|---|---|
| ARI | 8.25 | 8.91 | -0.66 |
| SF | 10.3 | 7.71 | 2.59 |
Yards Per Rush
| Name | Offense | Defense | Differential |
|---|---|---|---|
| ARI | 4.34 | 3.75 | 0.59 |
| SF | 3.28 | 3.7 | -0.42 |
Team Comparison
- ARI
- 20.7
- 17
- 3.7
- 165
- 111.3
- 264.3
- 76.3
- -0.7
- name
- offense
- defense
- differential
- passing yards
- rush yards
- pass yds allwd
- rush yds allwd
- t/o diff
- SF
- 19.7
- 16.3
- 3.3
- 271.3
- 89.7
- 162
- 103.7
- 0.3
Team Standings
Arizona Cardinals
| Name | Record | Home | Away | ATS | ATS Home | ATS Away | Offense | Defense | Diff |
|---|---|---|---|---|---|---|---|---|---|
| Overall | 2-0 | 1-0 | 1-0 | 1-1 | 0-1 | 1-0 | 23.5 | 17.5 | 6 |
| Last 3 | 2-0 | 1-0 | 1-0 | 1-1 | 0-1 | 1-0 | 23.5 | 17.5 | 6 |
| vs Conf | 2-0 | 1-0 | 1-0 | 1-1 | 0-1 | 1-0 | 0 | 0 | 0 |
| vs Div | 0-0 | 0-0 | 0-0 | 0-0 | 0-0 | 0-0 | 0 | 0 | 0 |
San Francisco 49ers
| Name | Record | Home | Away | ATS | ATS Home | ATS Away | Offense | Defense | Diff |
|---|---|---|---|---|---|---|---|---|---|
| Overall | 2-0 | 0-0 | 2-0 | 2-0 | 0-0 | 2-0 | 21.5 | 17 | 4.5 |
| Last 3 | 2-0 | 0-0 | 2-0 | 2-0 | 0-0 | 2-0 | 21.5 | 17 | 4.5 |
| vs Conf | 2-0 | 0-0 | 2-0 | 2-0 | 0-0 | 2-0 | 8.5 | 6.5 | 2 |
| vs Div | 1-0 | 0-0 | 1-0 | 1-0 | 0-0 | 1-0 | 17 | 13 | 4 |
Offense vs. Defense
| Title | Stat | Rank | Stat | Rank |
|---|---|---|---|---|
| Away Team Overall Scoring vs Home Team Overall Defense | 23.5 | 11 | 17 | 8 |
| Away Team Road Passing vs Home Team Home Passing Defense | 130 | 24 | 0 | 0 |
| Away Team Road Rushing vs Home Team Home Rushing Defense | 146 | 5 | 0 | 0 |
| Home Team Overall Scoring vs Away Team Overall Defense | 21.5 | 19 | 17.5 | 10 |
| Home Team Home Passing vs Away Team Road Passing Defense | 0 | 0 | 208 | 14 |
| Home Team Home Rushing vs Away Team Road Rushing Defense | 0 | 0 | 107 | 15 |
Head to Head
- ARI
- 5-5
- 5-5
- 6-4
- 22.3
- 134.4
- 4.8
- 36.4
- 68.7
- 226.9
- 361.3
- 1.3
- name
- record
- ATS
- OU
- score
- rush yds
- yds / rush
- att
- comp %
- pass yds
- total yds
- TO
- SF
- 5-5
- 5-5
- 6-4
- 27
- 142.8
- 5.3
- 30
- 65.3
- 233
- 375.8
- 1.1
Head to Head Breakdown
| Date | Away | Home | Score | Line | OU | ATY | HTY |
|---|---|---|---|---|---|---|---|
| Jan 5, 25 | SF | ARI | 24-47 | -4.5 | O 43 | 436 | 393 |
| Oct 6, 24 | ARI | SF | 24-23 | -7 | U 49 | 358 | 384 |
| Dec 17, 23 | SF | ARI | 45-29 | 12 | O 48 | 406 | 436 |
| Oct 1, 23 | ARI | SF | 16-35 | -14.5 | O 44 | 362 | 395 |
| Jan 8, 23 | ARI | SF | 13-38 | -14.5 | O 40 | 255 | 311 |
| Nov 21, 22 | SF | ARI | 38-10 | 9.5 | O 43 | 387 | 314 |
| Nov 7, 21 | ARI | SF | 31-17 | -5.5 | O 44.5 | 437 | 337 |
| Oct 10, 21 | SF | ARI | 10-17 | -6 | U 48.5 | 338 | 304 |
| Dec 26, 20 | SF | ARI | 20-12 | -6 | U 49 | 398 | 350 |
| Sep 13, 20 | ARI | SF | 24-20 | -7 | U 48.5 | 404 | 366 |
Team Last 5 Games
Arizona Cardinals
| Date | Opponent | Score | Result | Line | ATS Result | YDS For | YDS Allwd | TO | Location |
|---|---|---|---|---|---|---|---|---|---|
| Sep 14, 25 | CAR | 27-22 | W | -7/45.5 | L/O | 293 | 352 | -1 | H |
| Sep 7, 25 | NO | 20-13 | W | -5.5/44.5 | W/U | 276 | 315 | 0 | A |
| Jan 5, 25 | SF | 47-24 | W | -4.5/43 | W/O | 393 | 436 | -3 | H |
| Dec 28, 24 | LAR | 9-13 | L | 6.5/48 | W/U | 396 | 257 | 2 | A |
| Dec 22, 24 | CAR | 30-36 | L | -5.5/47 | L/O | 382 | 392 | 2 | A |
San Francisco 49ers
| Date | Opponent | Score | Result | Line | ATS Result | YDS For | YDS Allwd | TO | Location |
|---|---|---|---|---|---|---|---|---|---|
| Sep 14, 25 | NO | 26-21 | W | -3/40.5 | W/O | 344 | 307 | 0 | A |
| Sep 7, 25 | SEA | 17-13 | W | -2.5/43.5 | W/U | 384 | 230 | 0 | A |
| Jan 5, 25 | ARI | 24-47 | L | 4.5/43 | L/O | 436 | 393 | 3 | A |
| Dec 30, 24 | DET | 34-40 | L | 3.5/50.5 | L/O | 475 | 439 | 2 | H |
| Dec 22, 24 | MIA | 17-29 | L | -2/44 | L/O | 374 | 381 | 1 | A |