BUFFALO (2-4) at INDIANAPOLIS (1-5)

Sunday, 1 p.m. ET, CBS

OPENING LINE — Colts by 6½

RECORD VS. SPREAD — Buffalo 3-3, Indianapolis 2-4

SERIES RECORD — Bills lead 37-31-1

LAST MEETING — Bills beat Colts 13-7, OT, Dec. 10, 2017.

LAST WEEK — Bills lost to Texans 20-13; Colts lost to Jets 42-34

AP PRO32 RANKING — Bills No. 27, Colts No. 30

BILLS OFFENSE — OVERALL (31), RUSH (20, PASS (32).

BILLS DEFENSE — OVERALL (3), RUSH (8), PASS (6).

COLTS OFFENSE — OVERALL (17), RUSH (30), PASS (10).

COLTS DEFENSE — OVERALL (23), RUSH (16), PASS (26).

STREAKS, STATS AND NOTES — Bills have won three of last four in series, dating to 2010. ... Buffalo faces second straight road game vs. AFC South foe. ... QB Josh Allen left last week's game with sprained right elbow. Backup Nathan Peterman had interception returned for TD — decisive score in loss at Houston. ... Peterman started in last season's blizzard vs. Colts and helped lead Bills to victory, but Buffalo plans to start Derek Anderson. ... WR Kelvin Benjamin has 10 receptions this season despite being targeted 32 times. ... Bills allowed 21 sacks in first four games, just three in last two. ...LB Jerry Hughes faces rematch with team that drafted him in first round in 2010. ... Bills' defense is tied for league lead with seven fumble recoveries. ... Former Bills Jim Kelly, John Kidd and Thurman Thomas are among those expected to attend Frank Reich's first game as head coach against former team he led to greatest comeback in NFL history. ... Colts began week as one of five one-win teams in league. ... Indy has lost four straight overall and five of last six at Lucas Oil Stadium. ... Colts will try for fifth time to win game No. 300 since moving to Indy in 1984. ... K Adam Vinatieri needs 10 points to break Morten Andersen's career scoring record (2,544 points). Andersen played high school football in Indy. ... QB Andrew Luck has thrown at least one TD pass in league-high 29 consecutive games and will move into tie with Dan Marino, Ben Roethlisberger and Matt Ryan for No. 8 by extending streak to 30. ... Luck has thrown career-high 164 passes over last three games, with Colts topping 400 yards in total offense each time. ... TE Eric Ebron has six TD receptions, matching personal best for single season. ... Indy defense has forced two or more turnovers in four of six games this season. ... Game features two of NFL's best rookie linebackers: Darius Leonard and Tremaine Edmunds. Both are ranked among leagues' top four in tackles. Fantasy tip: With receiving corps depleted, Luck has been finding tight ends more often. That makes Ebron wise pick this week — if he stays healthy.

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