Dec 19, 2021; Santa Clara, California, USA; San Francisco 49ers defensive end Nick Bosa (97) signals during the fourth quarter against the Atlanta Falcons at Levi's Stadium. Mandatory Credit: Stan Szeto-USA TODAY Sports

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49ers favorites at Titans in pivotal game for both

Nick Bosa looks to continue sack rampage against quarterback when the San Francisco 49ers face the Tennessee Titans on Thursday night in a pivotal contest for both teams in Nashville.

Bosa has recorded at least one sack in six straight games and has racked up a career-high 15 for the season, which is tied for third in the NFL.

While Bosa’s first line of attack is helping San Francisco (8-6) move closer to landing an NFC playoff spot, the defensive end also has his eyes on the franchise single-season sack record held by Aldon Smith (19.5 in 2012).

“I’d like that,” Bosa said. “I definitely would like to have my name on there for this organization, but I’m also just trying to take it one day at a time.”

Bosa’s big campaign comes after he tore the ACL in his left knee in the second game of the 2020 season. His comeback and return to form have inspired teammates and impressed defensive coordinator DeMeco Ryans.

“He’s definitely been our MVP, and I’m so happy to have him on our side,” Ryans said. “I just love the way he works, love the way he brings other guys along with him. He’s everything you could ask for in a player.”

The 49ers currently own the sixth-best record in the NFC. They have won two games in a row and five of their past six heading into the matchup with the Titans (9-5).

Tennessee is sputtering, with three setbacks in its last four outings, but still leads the AFC South by one game over the Indianapolis Colts.

The 49ers’ are 3.0-point favorites at BetRivers and DraftKings and 3.5-point favorites at PointsBet. The action has been heavier on San Francisco’s spread line at all three sportsbooks.

The Over/Under is 44.5 points all three books as well. The action has been more split on that market, although 61.92 percent of the money has backed the Over at BetRivers.

The Titans also have to quickly push aside the disappointment of letting a 10-point lead get away Sunday in a 19-13 loss to the Pittsburgh Steelers.

“This will be a huge week to try and improve mentally; we won’t be able to do much physically,” Tennessee coach Mike Vrabel said. “And you have to prepare to win a game against a great opponent. It’s a great challenge: a team that’s won five of their last six games.”

The Titans haven’t been the same force since star running back Derrick Henry was lost with a foot injury in Week 8. Quarterback Ryan Tannehill has had to shoulder more of the load, and he has thrown for fewer than 200 yards in three straight games and four of six since Henry was hurt.

Tannehill also has thrown 11 interceptions over the past nine games — six coming during the current 1-3 stretch.

“We’ve just got to clean things up and take care of the ball, first and foremost,” Tannehill said. “We have done some good things over the last month, but turnovers have killed us.”

The passing game will receive a boost as receiver A.J. Brown was activated prior to Thursday’s game after missing the past three games due to a chest injury. Brown has 46 receptions for 615 yards and three touchdowns in 10 games.

Wideout Julio Jones (hamstring) returned to practice Wednesday, three days after leaving the loss to the Steelers. He is expected to play and has no injury designation on the official injury report.

But the Titans are facing challenges on the offensive line. Three-time Pro Bowl left tackle Taylor Lewan (back), left guard Rodger Saffold (shoulder, COVID-19) and key backup Kendall Lamm (COVID-19) will sit out the game. Lamm, who was slated to start for Lewan, announced his positive COVID-19 test on Thursday afternoon.

Tennessee also activated safety Chris Jackson (foot) off injured reserve before the game.

San Francisco will be without leading rusher Elijah Mitchell (759 yards), who didn’t practice all week, for the third straight game.

Mitchell missed San Francisco’s 31-13 victory over the Atlanta Falcons on Sunday due to a concussion and a knee injury. He cleared the concussion protocol, and the 49ers were hoping the knee would improve and allow him to play.

Jeff Wilson Jr., who rushed for a season-best 110 yards against Atlanta, will be the main back.

Tight end George Kittle is on a three-game roll in which he has caught 28 passes for 425 yards and three touchdowns.

San Francisco has won the past two meetings with Tennessee, including a 31-17 decision in 2013 when the teams last met in Nashville.

–Field Level Media

Field Level Media
Sport Writer & Editor
FLM has a North American focus while tying into regional and hyper-local resources – providing the ability to distribute compelling content through the writing of professional journalists. As the U.S. sports content provider to dozens of digital and print media publishers through strategic partnerships with the likes of Reuters and Nielsen Sports, FLM covers the nuts and bolts with a breaking news desk and game event coverage.

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