October 3, 2021; Santa Clara, California, USA; San Francisco 49ers quarterback Jimmy Garoppolo (10) passes the football against the Seattle Seahawks during the first quarter at Levi's Stadium. Mandatory Credit: Kyle Terada-USA TODAY Sports

News Articles

49ers QB Jimmy Garoppolo (calf) departs, Trey Lance takes over

San Francisco 49ers quarterback Jimmy Garoppolo suffered a calf injury during Sunday’s 28-21 loss to the visiting Seattle Seahawks and sat out the second half.

Rookie Trey Lance, the No. 3 overall pick in last April’s draft, took over at quarterback to start the second half. Lance had been used sparingly in special packages during the first three weeks of the season while Garoppolo remained the 49ers’ No. 1 quarterback.

Garoppolo went 14-for-23 for 165 yards, one touchdown and one interception in the first half. The score was knotted 7-7 at halftime.

Lance finished 9-for-18 for 157 passing yards, two touchdowns and 41 rushing yards, but could not surmount Seattle’s lead.

Left tackle Trent Williams also left the game with cramps.

–Field Level Media

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