Uncertainty around the Covid-19 situation with Tennessee delayed these odds and delayed this game, but now the Buffalo Bills are road favorites in a rare Tuesday night NFL matchup.
It’s a battle of unbeatens, as the Titans are 3-0 and the Bills are 4-0. Tennessee already had one game pushed later in the season after dozens of positive Covid-19 tests. Making this Bills Titans pick is the most difficult task of the week by far.
Bills vs Titans Odds: Tennessee +3.5, Total 52.5 | Matchup Report
Why the Bills can cover the spread
Buffalo appears to be legit contenders and remain settled at 14-1 in Super Bowl futures, the highest the Bills have been in years. And they boast a Top 10 rated run defense, which will be tested by Derrick Henry and the Titans.
The Bills have remained active in practice while the Titans have been distracted and unable to fully prepare while working through the Covid-19 mess.
On the trend site, Buffalo always seems to win SU as favored, as they are on a 18-3 SU run in this situation. And they encounter a team that for some reason struggles in Week 5, with a 1-7-1 ATS mark in the past nine seasons.