Baltimore is the biggest road favorite off the year, despite coming off a loss on a short week.
Tampa Bay is favored at home by a TD for just the fifth time in a decade.
The Giants are double-digit road dogs for just the fourth time since 2004.
And New England is the biggest ‘real’ underdog of 7 or more in a decade, when they visit Kansas City. We say ‘real’ because the two most recent times the Patriots laid 7 was Week 1 of 2016 when Tom Brady was suspended over DeflateGate and a meaningless 2010 Week 17 game at Houston.
Week 4 opening lines in the NFL feature the biggest home dog and the biggest home favorite of the year so far. LA Rams, fresh off a rally that fell just short in Buffalo, are -14 at home to the Giants, who were pulverized by an injury-riddled 49ers team.
Seattle, which jumped to 10-1 odds on this week Super Bowl futures board, is also a big road favorite, laying seven points at Miami.
Check out the opening odds and follow line moves and updates all week in our NFL odds section.