Best Betting Sites

Week 4 Opening Lines

Baltimore is the biggest road favorite off the year, despite coming off a loss on a short week.

Tampa Bay is favored at home by a TD for just the fifth time in a decade.

The Giants are double-digit road dogs for just the fourth time since 2004.

And New England is the biggest ‘real’ underdog of 7 or more in a decade, when they visit Kansas City. We say ‘real’ because the two most recent times the Patriots laid 7 was Week 1 of 2016 when Tom Brady was suspended over DeflateGate and a meaningless 2010 Week 17 game at Houston.

Week 4 opening lines in the NFL feature the biggest home dog and the biggest home favorite of the year so far. LA Rams, fresh off a rally that fell just short in Buffalo, are -14 at home to the Giants, who were pulverized by an injury-riddled 49ers team.

Seattle, which jumped to 10-1 odds on this week Super Bowl futures board, is also a big road favorite, laying seven points at Miami.

Check out the opening odds and follow line moves and updates all week in our NFL odds section.

Week 4 Opening Lines

Denver Broncos -3 New York JetsMatchup Report

  • O40.0 (-110)
  • U40.0 (-110)

Arizona Cardinals -4 Carolina PanthersMatchup Report

  • O52.5 (-110)
  • U52.5 (-110)

Cleveland Browns +4.5 Dallas CowboysMatchup Report

  • O55.5 (-105)
  • U55.5 (-115)

Indianapolis Colts -3 Chicago BearsMatchup Report

  • O45.0 (-110)
  • U45.0 (-110)

Jacksonville Jaguars +3 Cincinnati BengalsMatchup Report

  • O48.0 (-115)
  • U48.0 (-105)

Los Angeles Chargers +7.5 Tampa Bay BuccaneersMatchup Report

  • O45.0 (-110)
  • U45.0 (-110)

Minnesota Vikings +4 Houston TexansMatchup Report

  • O54.5 (-115)
  • U54.5 (-105)

New Orleans Saints -4 Detroit LionsMatchup Report

  • O54.0 (-110)
  • U54.0 (-110)

Pittsburgh Steelers -1.5 Tennessee TitansMatchup Report

  • O47.0 (-115)
  • U47.0 (-105)

Seattle Seahawks -7 Miami DolphinsMatchup Report

  • O54.5 (-110)
  • U54.5 (-110)

New York Giants +13 Los Angeles RamsMatchup Report

  • O47.5 (-110)
  • U47.5 (-110)

Buffalo Bills -3 Las Vegas RaidersMatchup Report

  • O52.0 (-115)
  • U52.0 (-105)

Philadelphia Eagles +6.5 San Francisco 49ersMatchup Report

  • O45.0 (-110)
  • U45.0 (-110)

Monday Night football Opening Odds

Atlanta Falcons +7.5 Green Bay PackersMatchup Report

  • O58.0 (-110)
  • U58.0 (-110)