Sep 17, 2023; Glendale, Arizona, USA; Arizona Cardinals safety K'Von Wallace (22) tackles New York Giants running back Saquon Barkley (26) during the first half at State Farm Stadium. Mandatory Credit: Joe Camporeale-USA TODAY Sports

Giants RB Saquon Barkley (ankle) ruled out vs. 49ers

New York Giants star running back Saquon Barkley has been ruled out of Thursday’s road game against the San Francisco 49ers due to a sprained ankle.

Giants coach Brian Daboll initially told reporters on Tuesday that Barkley would be a game-time decision against the 49ers (2-0). On Wednesday, the team’s injury report listed Barkley as out, along with offensive linemen Andrew Thomas (hamstring) and Ben Bredeson (concussion) as well as linebacker Azeez Ojulari (hamstring).

Barkley and Bredeson did not practice on Wednesday, while Thomas, Ojulari joined wide receiver Wan’Dale Robinson (knee) and linebacker Micah McFadden (neck) in being limited. Robinson and McFadden are listed as questionable to face San Francisco.

Barkley, 26, hurt his right ankle during the Giants’ game-winning drive in a 31-28 road win over the Arizona Cardinals. He took a 2-yard carry up the middle and appeared to get his ankle caught under Arizona linebacker Krys Barnes with 1:08 left in the game.

Through two games, Barkley has rushed for 114 yards and one touchdown on 29 carries and caught nine passes for 41 yards and another score for the Giants (1-1).

Barkley missed time with ankle injuries in 2019 and 2021. His 2020 season was also cut short due to a torn ACL in Week 2.

Running back Matt Breida will receive increased playing time in the absence of Barkley. Breida, 28, carried the ball 54 times for 220 yards (4.1 yards per carry) in 17 games with the Giants last season.

–Field Level Media

Sep 26, 2021; E. Rutherford, N.J., USA;  New York Giants wide receiver Sterling Shepard (3) carries the ball as Atlanta Falcons linebacker Foye Oluokun (54) defends in the first half at MetLife Stadium. Mandatory Credit: Robert Deutsch-USA TODAY Sports

Giants without two top receivers vs. Saints

The New York Giants on Friday ruled out receivers Sterling Shepard and Darius Slayton, as well as left guard Ben Bredeson, from Sunday’s game against the New Orleans Saints.

Shepard and Slayton are dealing with hamstring injuries while Bredeson has a hand ailment. All three were injured during last week’s 17-14 loss to the Atlanta Falcons and missed all three practices this week.

Shepard leads the Giants (0-3) with 18 receptions for 223 yards. Slayton is the team’s fourth leading receiver with seven catches for 127 yards. The Giants have just two TD receptions, with Shepard and Slayton grabbing one each.

Kenny Golladay with 11 catches for 166 yards is the only other New York wideout over 100 receiving yards.

Bredeson’s injury leaves the Giants needing a new starting left guard for the fourth straight week.

Shane Lemieux started the opener but was lost for the season with a knee injury. Center Nick Gates moved to left guard for the second game but broke his leg.

Bredeson’s injury means the Giants will likely turn to veteran Matt Skura at the position. Skura worked at left guard all week in practice sessions.

Also, special teams standout Nate Ebner (quadriceps) is one of four players listed as questionable. The others are cornerback Keion Crossen (elbow), linebacker Tae Crowder (hamstring) and tight end Kaden Smith (knee).

–Field Level Media