Sep 21, 2025; Santa Clara, California, USA; San Francisco 49ers quarterback Mac Jones (10) throws downfield as Arizona Cardinals linebacker Jordan Burch (52) defends during the second half at Levi's Stadium. Mandatory Credit: Kyle Terada-Imagn Images

Jaguars to test unbeaten, battered 49ers

Even while riding a quarterback carousel early this season, the San Francisco 49ers are one of six undefeated teams through three weeks.

Starter Brock Purdy was sidelined the last two games with turf toe, but Mac Jones has taken the reins, leading the 49ers to wins over New Orleans and Arizona.

Now, there’s some uncertainty if either of them will be available for Sunday’s game against the Jacksonville Jaguars in Santa Clara, Calif.

Purdy (left shoulder/toe) and Jones (knee) were limited in Wednesday’s practice. 49ers head coach Kyle Shanahan said before the practice that both would get fewer first-team reps than usual, and third-string quarterback Adrian Martinez will get a larger share.

“(Brock) is better today than he was on Sunday. Hopefully, that will keep continuing,” Shanahan said.

Martinez, 25, signed with the 49ers (3-0) in August after he was waived by the New York Jets. He was elevated from the practice squad to be the backup last week with Purdy inactive and has never appeared in a regular-season NFL game.

Whoever gets the start at QB, they could have a limited group of skill-position players around them. Tight end George Kittle (hamstring) remains out, and receivers Ricky Pearsall (knee), Jauan Jennings (ankle/shoulder) and Jordan Watkins (calf) all missed Wednesday’s practice.

The Jaguars (2-1) are coming off their first home win over Houston since 2017. Now, they seek their first win at San Francisco. They’ve lost both trips there and the last five games in the series.

For the second time in three games, Jacksonville’s defense didn’t allow a touchdown until the fourth quarter of last week’s 17-10 win over the Texans. The Jags are tied for fifth in scoring defense (17.0 points per game), 10th in total defense (292.0 yards per game) and lead the league with nine forced turnovers, as many as they had all of last season, which was last in the NFL.

Jacksonville rookie Travis Hunter has played a greater role in that success over the last two weeks. After playing largely on offense in Week 1, the No. 2 overall pick has been a true two-way player the last two weeks, playing at least 37 snaps on both offense and defense in each game.

He enters Sunday’s game with 10 catches for 76 yards on offense and nine tackles with one pass breakup on defense. He had six tackles (one off the team lead) and a shifty 21-yard catch in the Houston win.

To keep things as simple as possible, Jacksonville is limiting Hunter to a specific position on each side of the ball as a rookie.

“We had a great talk with Trav after this past game in terms of just, ‘How can we help you?’ Because what is he learning? It’s a lot,” Jaguars head coach Liam Coen said. “We’ve got to, I think, be a little more diligent in terms of putting him in positions to maybe not have to do as many moving parts so that we can let him go play.”

The San Francisco defense took a hit Sunday when five-time Pro Bowl edge rusher Nick Bosa sustained a season-ending knee injury. Losing a player who had nine-plus sacks each of the last four seasons will hinder a defense which ranks third in scoring defense (16.3) and fourth in total defense (265.7).

It puts an onus on players like rookie first-round pick Mykel Williams and veteran defensive end Bryce Huff (22 career sacks), whom the 49ers traded for in June, to rise to the challenge.

“We’re calling on a lot of guys who probably didn’t know that they were going to be needed as much as they have been,” 49ers linebacker Fred Warner said.

Additionally for San Francisco, defensive end Yetur Gross-Matos (knee) and defensive tackle C.J. West (thumb) did not practice Wednesday while cornerbacks Renardo Green (neck) and Deommodore Lenoir (illness), guard Connor Colby (groin) and defensive tackle Kalia Davis (ankle) were limited.

Wide receiver Dyami Brown (shoulder) was the only active Jacksonville player who did not practice Wednesday. Running back Bhayshul Tuten (shoulder) and guards Ezra Cleveland (ankle), Patrick Mekari (elbow) and Wyatt Milum (knee) were limited.

–Field Level Media

Sep 21, 2025; Santa Clara, California, USA; San Francisco 49ers quarterback Mac Jones (10) throws the ball against the Arizona Cardinals during the first half at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

49ers QB Mac Jones gives update after re-aggravating knee injury

San Francisco quarterback Mac Jones re-aggravated a sprained PCL during the 49ers’ 16-15 victory over the Arizona Cardinals, he told reporters after the game Sunday in Santa Clara, Calif.

Jones, 27, sustained the ligament injury in training camp but was healthy in time for the regular season, when he was the backup to starter Brock Purdy. However, Purdy came away from the season-opening win against the Seattle Seahawks with toe and left shoulder injuries, his toe being the bigger concern. He has missed the last two games, both San Francisco victories with Jones behind center.

Jones completed 27 of 41 passes for 284 yards, one touchdown and one interception against Arizona (2-1). He was 26-of-39 passing for 279 yards, three touchdowns and no interceptions in a 26-21 win at New Orleans on Sept. 14.

Purdy was listed as questionable for Sunday before being ruled out before the game.

The New England Patriots selected Jones with the 15th overall pick of the 2021 NFL Draft. Jones is in his first season as San Francisco’s backup after three bumpy years in New England and one season in Jacksonville.

–Field Level Media

Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers quarterback Brock Purdy (13) reacts after the game against the Seattle Seahawks during the fourth quarter at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images

Early return? 49ers QB Brock Purdy limited in practice Wednesday

San Francisco quarterback Brock Purdy was a limited participant in practice Wednesday and has a chance to play on Sunday, 49ers coach Kyle Shananah said.

Toe and shoulder injuries kept Purdy on the sideline for San Francisco’s 26-21 win at New Orleans last week. He has a form of turf toe and was expected to miss multiple weeks. In a spot start, backup Mac Jones completed 26 of 39 passes for 279 yards and three touchdowns without an interception.

The 49ers (2-0) play their home opener on Sunday against the Arizona Cardinals (2-0).

Purdy, 25, is nursing left shoulder and toe ailments after completing 26 of 35 passes for 277 yards, two TDs and two interceptions in the season-opening 17-13 victory at the Seattle Seahawks.

San Francisco placed starting left guard Ben Bartch on injured reserve on Wednesday due to a high ankle sprain. The team promoted tight end Brayden Willis to the active roster and signed offensive lineman Brandon Parker to the practice squad.

Shanahan also said guard Spencer Burford (knee), defensive end Yetur Gross-Matos (knee), fullback Kyle Juszczyk (concussion) and safety Siran Neal (concussion) will sit out practice.

Wednesday is a scheduled rest day for defensive end Nick Bosa, running back Christian McCaffrey and left tackle Trent Williams.

–Field Level Media

Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers quarterback Brock Purdy (13) runs the ball during the first half against the Seattle Seahawks at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images

49ers QB Brock Purdy out; Mac Jones to start vs. Saints

San Francisco 49ers quarterback Brock Purdy did not practice this week while nursing left shoulder and toe ailments, and on Friday he was ruled out of Sunday’s game at the New Orleans Saints.

Starting under center in Purdy’s place will be Mac Jones, who took all the first-team reps in practice on Wednesday, Thursday and Friday ahead of his first start with the 49ers. The 2021 first-round pick (No. 15 overall) of the New England Patriots signed a two-year deal for $7 million in March.

“Mac’s been awesome,” head coach Kyle Shanahan told reporters this week. “Our team really believes in him.”

As for Purdy, general manager John Lynch on Thursday told KNBR radio that the fourth-year signal-caller is “week to week.”

“Brock is doing well,” Lynch told KNBR. “He’s doing a nice job, doing everything he can to get back out there as soon as possible. … But that’s where we’re at, on a week-to-week deal.”

Shanahan told reporters this week that Purdy’s toe injury could keep him for multiple weeks.

Purdy, 25, completed 26 of 35 passes for 277 yards with two TDs and two picks in the season-opening 17-13 victory at Seattle. The 2023 Pro Bowl selection is 24-13 as the starter since being selected with the 262nd and final pick in the 2022 NFL Draft.

Jones, who turned 27 last week, played 10 games with the Jacksonville Jaguars in 2024 after three seasons with the Patriots.

Jones is 20-29 in his career as a starter, completing 65.9 percent of his passes for 10,590 yards with 54 touchdowns and 44 interceptions. He made the Pro Bowl after his rookie campaign.

Adrian Martinez, who has not played in an NFL game, will be elevated to the active roster to back up Jones. Martinez, 25, served as a backup for the New York Jets for one game last season. He’s also spent time with the Detroit Lions.

Already without star tight end George Kittle, who was placed on injured reserve earlier this week with a hamstring injury, the 49ers may be without Jauan Jennings (shoulder) and left tackle Trent Williams (knee), who are questionable. Both missed practice on Wednesday and Thursday but did light work on Friday.

–Field Level Media

Jan 5, 2025; Glendale, Arizona, USA; San Francisco 49ers offensive tackle Colton McKivitz (68) against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images

49ers RT Colton McKivitz lands 3-year, $45M extension

The 49ers and Colton McKivitz have agreed to a three-year, $45 million contract that keeps the right tackle in San Francisco through the 2028 season.

The deal includes $27 million guaranteed, agents Doug Hendrickson and CJ LaBoy confirmed to ESPN on Monday.

McKivitz, 29, has started 40 of 63 games since the 49ers drafted him in the fifth round in 2020, including Sunday’s season-opening win at Seattle.

McKivitz indicated last week that the two sides were working on an extension.

“I think it’s pretty open right now,” he told reporters on Wednesday. “Nothing crazy is going on but both sides have said that we want to be here, which I do. I love playing here. I love being a part of this team and they’ve reciprocated that. So when it does come, I’d be excited for it, but we’ll see.”

McKivitz earns a significant pay bump from the one-year, $7 million extension he signed in March 2024.

–Field Level Media

Aug 9, 2025; Santa Clara, California, USA;  San Francisco 49ers running back Ameer Abdullah (38) rushes the ball past Denver Broncos nose tackle Jordan Miller (90) in the third quarter at Levi's Stadium. Mandatory Credit: David Gonzales-Imagn Images

49ers place RB Ameer Abdullah on IR, sign RB Jeff Wilson Jr., DL Trevis Gipson

Ameer Abdullah’s stay on the San Francisco 49ers’ active roster was brief as the veteran running back was placed on season-ending injured reserve on Monday after a rib issue sustained in Saturday’s preseason opener against the Denver Broncos.

The 49ers, who signed Abdullah on July 31, inked running back Jeff Wilson Jr. and defensive lineman Trevis Gipson to one-year contracts on Monday. The team cut quarterback Tanner Mordecai and activated offensive lineman Andre Dillard from the physically unable to perform list.

Head coach Kyle Shanahan said on Monday that rookie wide receiver Jordan Watkins is expected to be out about a month due to a high ankle sprain and that former starting receiver Brandon Aiyuk (ACL) is estimated to return around Week 6 of the regular season, though the situation could change. Watkins, 23, was a fourth-round pick in the 2025 NFL Draft.

Aiyuk, 27, is battling back from a serious right knee injury that included tears to the ACL and MCL. He was injured in Week 7 of last season and went on injured reserve, and he was placed on the PUP list on July 18.

Abdullah, 32, played in 16 games (three starts) for the Las Vegas Raiders last season and rushed 66 times for 311 yards and two touchdowns, while catching 40 passes for 261 yards and three scores. He took 410 offensive snaps (38 percent) and 192 on special teams (43 percent).

For his career, Abdullah has rushed for 1,994 yards and eight TDs and caught 203 passes for 1,468 yards and 11 scores in 141 regular-season games (26 starts) for the Detroit Lions (2015-18), Minnesota Vikings (2018-21), Carolina Panthers (2021) and Raiders (2022-24). The Lions selected him in the second round of the 2015 draft.

Gipson, 28, has played in 53 career games (19 starts) for the Chicago Bears (2020-22), Tennessee Titans (2023) and Seattle Seahawks (2024). His best season was in 2021 when he started nine of 16 games for the Bears as an outside linebacker and had career highs with seven sacks, 39 tackles, five forced fumbles and one fumble recovery.

Chicago picked him in the fifth round of the 2020 draft.

Wilson, 29, played the first four-plus years of his NFL career in San Francisco before spending the past three seasons in Miami.

The 2018 undrafted free agent rushed for 1,733 yards and 15 touchdowns with San Francisco, which traded the running back to Miami midway through the 2022 season.

Wilson ran for just 637 yards and three scores in Miami, appearing in only 19 games (no starts) over the past two years.

Mordecai, 25, spent last season on the 49ers’ practice squad.

Dillard, 29, was a first-round pick (22nd overall) by the Philadelphia Eagles in 2019. He played in 69 games (19 starts) for the Eagles (2019, 2021-22), Titans (2023) and Green Bay Packers (2024) before signing with the 49ers in May. He went on the active/PUP list on July 18 for an undisclosed injury.

–Field Level Media

Nov 10, 2024; Inglewood, California, USA; Los Angeles Chargers cornerback Eli Apple (41) and Tennessee Titans cornerback Justin Hardee Sr. (26) during the fourth quarter at SoFi Stadium. Mandatory Credit: Robert Hanashiro-Imagn Images

Agency: 49ers signing veteran CB Eli Apple

Veteran cornerback Eli Apple will have a chance to play for his seventh NFL team after agreeing to a one-year contract with the San Francisco 49ers, his agency said on social media Sunday.

The 49ers had not made an announcement as of Sunday night. Apple, who turns 30 on Aug. 9, was limited by a hamstring injury last season and played in only four regular-season games and one playoff appearance for the Los Angeles Chargers, making two tackles.

He has 383 career tackles, six interceptions, 61 passes defended, three forced fumbles and seven fumble recoveries in 102 regular-season games (82 starts) for the New York Giants (2016-18), New Orleans Saints (2018-19), Carolina Panthers (2020), Cincinnati Bengals (2021-22), Miami Dolphins (2023) and Chargers.

The Giants selected Apple with the 10th overall pick of the 2016 NFL Draft.

–Field Level Media

Aug 17, 2024; Houston, Texas, USA; Houston Texans wide receiver Quintez Cephus (81) before the game against the New York Giants at NRG Stadium. Mandatory Credit: Troy Taormina-Imagn Images

49ers sign WR Quintez Cephus, cut RB Israel Abanikanda

The San Francisco 49ers signed wide receiver Quintez Cephus to a one-year deal on Thursday and waived running back Israel Abanikanda.

Cephus, 27, was a fifth-round pick by Detroit in the 2020 NFL Draft and last appeared in a game with the Lions in 2022. The league suspended him for the 2023 season for betting on NFL games.

Cephus caught 37 passes for 568 yards and four touchdowns in 22 games (six starts) for Detroit from 2020-22. After being reinstated by the league in April 2024, he spent time with the Buffalo Bills, Houston Texans and Los Angeles Rams.

The 49ers needed another wideout after Jacob Cowing sustained a hamstring injury in Wednesday’s practice.

Abanikanda, 22, was a fifth-round pick by the New York Jets in 2023. He rushed 22 times for 70 yards and caught seven passes for 43 yards in six games with the Jets in 2023. The 49ers claimed him off waivers in December 2024.

–Field Level Media

Sep 9, 2024; Santa Clara, California, USA; San Francisco 49ers safety George Odum (30) celebrates in the fourth quarter against the New York Jets at Levi's Stadium. Mandatory Credit: David Gonzales-Imagn Images

49ers release veteran safety, special teams standout George Odum

The San Francisco 49ers released veteran safety George Odum on Saturday, one day after placing him on the active/non-football injury list.

Odum, 31, played 12 games for the 49ers last season (two starts) and recorded 11 tackles on defense and a career-high four passes defended, as well as five tackles on special teams.

He made The Associated Press’ Second-Team All-Pro for special teams in 2022, when he led the league with 21 special teams tackles in his first season with San Francisco. He also made the AP First-Team All-Pro in 2020 with the Indianapolis Colts, also for special teams.

Odum has totaled 200 tackles, three interceptions, nine passes defended, four forced fumbles and two fumble recoveries in 105 games (12 starts) for the Colts (2018-21) and 49ers (2022-24).

–Field Level Media

Oct 20, 2024; Santa Clara, California, USA; San Francisco 49ers cornerback Deommodore Lenoir (2) flexes before the start of the game against the Kansas City Chiefs at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

Report: 49ers CB Deommodore Lenoir arrested in L.A.

San Francisco 49ers cornerback Deommodore Lenoir was arrested in Los Angeles on Thursday night on a charge of obstruction of justice, police said.

Lenoir, 25, was released from jail early Friday morning and is scheduled to appear in court next month, according to multiple reports.

According to the Los Angeles Police Department, officers approached a group that included Lenoir and observed a gun inside a parked vehicle.

When police asked for the keys, another man tossed them to Lenoir. Lenoir then threw the keys to a third man who tried to hide them, according to records and statements obtained by NBC Bay Area.

The 49ers have not released a statement on the matter.

Lenoir signed a five-year, $92 million extension last November with the 49ers, who drafted the Los Angeles native in the fifth round in 2021.

Lenoir has recorded six interceptions, 26 passes defensed and 265 tackles in 62 games (47 starts) through his first four seasons with San Francisco.

–Field Level Media