October 3, 2021; Santa Clara, California, USA; San Francisco 49ers quarterback Jimmy Garoppolo (10) passes the football against the Seattle Seahawks during the first quarter at Levi's Stadium. Mandatory Credit: Kyle Terada-USA TODAY Sports

Jimmy Garoppolo (calf) still has chance to play Sunday

Injured San Francisco quarterback Jimmy Garoppolo missed another practice Thursday but has not yet been ruled out for the 49ers’ Sunday road game against the Arizona Cardinals.

Niners coach Kyle Shanahan said Thursday that Garoppolo “wants to give it a go” Friday on his strained right calf.

“We’ll see him out on the practice field (Friday),” Shanahan said on KNBR Radio. “If he looks good, then he’ll have a shot. If he can’t, then we’ll shut him down.”

Rookie Trey Lance is poised to make his first NFL start for San Francisco (2-2) against the Cardinals (4-0) if Garoppolo is unable to go.

“If he feels good enough to where he can protect himself, he feels confident to step into all his throws, Jimmy’s been here long enough, and he’s not a guy who’s just sitting here and rehabbing all week and checked out,” Shanahan said on KNBR. “He’s a guy who, besides the practice field, you would think he was starting.”

Garoppolo sustained the injury in the first half of San Francisco’s 28-21 loss to Seattle last Sunday. Garoppolo completed 14 of 23 passes for 165 yards, one touchdown and one interception in the first half. The score was knotted 7-7 at halftime.

Lance, the No. 3 overall pick in this year’s draft, took over at quarterback to start the second half.

Offensive tackle Trent Williams (shoulder) was a full participant in Thursday’s practice and is good to go Sunday. He missed Wednesday’s practice.

However, cornerback K’Waun Williams (calf) has been ruled out for Sunday, according to Shanahan.

Tight end George Kittle (calf) also missed his second consecutive practice Thursday.

–Field Level Media

October 11, 2020; Santa Clara, California, USA; San Francisco 49ers offensive tackle Trent Williams (71) walks off the field after the game against the Miami Dolphins at Levi's Stadium. Mandatory Credit: Kyle Terada-USA TODAY Sports

49ers shut down LT Trent Williams with knee issue

Trent Williams is being shut down for the rest of the week by the San Francisco 49ers after the highest-paid offensive tackle in the NFL needed fluid drained from around his ailing knee.

Williams, 33, is set to be evaluated early next week, head coach Kyle Shanahan said Thursday.

Williams was an unrestricted free agent in the offseason but re-signed with the 49ers. The six-year deal worth up to $138.1 million reportedly included a $30.1 million signing bonus and $55.1 million guaranteed.

The eight-time Pro Bowl selection was acquired by the 49ers from the Washington Football Team after sitting out the entire 2019 season in what Williams said was a health-related contract situation.

He played 14 games for the 49ers last season and has played in 134 games (133 starts) in his career.

Shanahan also said wide receiver Jalen Hurd will join Williams on the sideline for the week because he’s fighting knee tendinitis related to recovery from his torn ACL.

–Field Level Media

Nov 29, 2020; Inglewood, California, USA; San Francisco 49ers offensive tackle Trent Williams (71) before the game against the Los Angeles Rams  at SoFi Stadium. Mandatory Credit: Kirby Lee-USA TODAY Sports

49ers make Trent Williams NFL’s top-paid OL

San Francisco 49ers left tackle Trent Williams is set to become the highest-paid offensive lineman in the NFL to kick off free agency on Wednesday.

Williams, 32, agreed to a six-year deal worth up to $138.1 million with the 49ers — the richest deal for an offensive lineman in league history. He’ll receive $55.1 million guaranteed and $30.1 million as a signing bonus, according to multiple reports.

Williams was the top-rated free agent offensive tackle available.

The eight-time Pro Bowl left tackle was acquired by the 49ers from the Washington Football Team after sitting out the entire 2019 season in what Williams said was a health-related contract situation.

He played 14 games for the 49ers last season and has played in 134 games (133 starts) in his career.

–Field Level Media