Cincinnati Bengals running back Jacques Patrick (31) runs the ball during training camp practice at the Paul Brown Stadium practice field in downtown Cincinnati on Monday, Aug. 2, 2021.

Cincinnati Bengals Camp

49ers sign RB Jacques Patrick off Bengals’ practice squad

The San Francisco 49ers signed running back Jacques Patrick off the Cincinnati Bengals’ practice squad Tuesday, according to multiple reports.

Undrafted out of Florida State in 2019, Patrick led the Bengals with 156 rushing yards and a touchdown during the 2021 preseason.

The injury-depleted 49ers (2-0) host the Green Bay Packers (1-1) on Sunday night.

San Francisco lost starting running back Raheem Mostert to season-ending knee surgery after Week 1. Elijah Mitchell left Sunday’s win at Philadelphia with a shoulder injury and was replaced by JaMycal Hasty, who wound up leaving the game with high-ankle sprain. Rookie Trey Sermon then suffered a head injury and fullback Kyle Juszcyk left the field with leg cramps.

Head coach Kyle Shanahan on Monday said Mitchell and Sermon “have a chance” to play this weekend. Hasty is expected to miss a few weeks.

Shanahan also said former Detroit Lions running back Kerryon Johnson could be activated from the practice squad.

–Field Level Media

Sep 12, 2021; Detroit, Michigan, USA; San Francisco 49ers linebacker Dre Greenlaw (57) runs after an interception during the second quarter against the Detroit Lions at Ford Field. Mandatory Credit: Raj Mehta-USA TODAY Sports

49ers place LB Dre Greenlaw on injured reserve

The San Francisco 49ers placed starting linebacker Dre Greenlaw on injured reserve Saturday.

He suffered a groin injury in last Sunday’s season-opening 41-33 win over the Detroit Lions. The team announced earlier this week that he will have surgery to repair a core muscle injury, but he is expected to return this season.

Greenlaw, 24, left the game after returning an interception 39 yards for a touchdown late in the second quarter. He finished with six tackles.

A fifth-round pick by the 49ers in 2019, Greenlaw has 184 tackles, two sacks and two interceptions in 30 career games (23 starts).

He must remain on IR for a minimum of three weeks, meaning the earliest he could return to the lineup would be the Week 5 game at Arizona. However, head coach Kyle Shanahan said Friday that Greenlaw will likely miss four to six weeks.

–Field Level Media

Aug 19, 2021; Philadelphia, Pennsylvania, USA; Philadelphia Eagles wide receiver DeVonta Smith (6) warms up before action against the New England Patriots at Lincoln Financial Field. Mandatory Credit: Bill Streicher-USA TODAY Sports

Eagles open at home with road-tested 49ers

Reigning Heisman Trophy winner DeVonta Smith gets another shot at a team that passed on him in the draft when the Philadelphia Eagles welcome the San Francisco 49ers on Sunday afternoon in a battle of Week 1 winners.

The wide out debuted for the Eagles (1-0) in their 32-6 win at Atlanta last Sunday, contributing six catches for 71 yards, including an 18-yard hook up with Jalen Hurts that produced Philadelphia’s first points of the season.

The 49ers (1-0) opened with an impressive offensive showing on the road, getting 189 receiving yards and a touchdown from Deebo Samuel in a 41-33 victory at Detroit.

The Falcons and 49ers entered the April draft with concerns at wideout. Atlanta was on the verge of trading longtime standout Julio Jones to the Tennessee Titans, while San Francisco was coming off a season in which its top pass-catcher — Brandon Aiyuk — totaled just 748 receiving yards on 60 receptions.

The 49ers opted for quarterback Trey Lance with the No. 3 selection. Lance debuted against the Lions as a backup, a role in which he threw a 5-yard touchdown pass on his only attempt. He saw action on just three other plays, rushing for 2 yards on three attempts.

The Falcons indeed plucked a pass catcher one pick later. But it was Florida tight end Kyle Pitts, who was limited to four catches for 31 yards in his duel with Smith in the opener.

Smith went 10th to the Eagles, which will give the former Alabama standout six personal incentives this season to show what teams missed out on by selecting other players. Philadelphia doesn’t play Jacksonville, Cincinnati or Miami in 2021, three other teams that went elsewhere on the draft board.

Smith won’t be the only Eagles player performing before the Philadelphia fans for the first time this week. New head coach Nick Sirianni looks forward to the hometown fans’ reaction to his unbeaten squad.

“What a great football city this is. Fans are the best in the NFL,” Sirianni said. “Super excited to feel that energy, to feel that energy when we come out. I’m going to be looking at that screen when Rocky comes on and Adrian says, ‘Win,’ and everybody gets juiced up. I’m going to have some energy when I see that.”

A home crowd filled with energy last week at Detroit was quickly quieted. Lance threw his touchdown pass to Trent Sherfield in the game’s 10th minute, and San Francisco led 31-10 by halftime.

Before the game ended, the 49ers found themselves holding on for dear life, in part because two key players — running back Raheem Mostert and cornerback Jason Verrett – came away with season-ending injuries.

Rookie Elijah Mitchell stepped in for Mostert and delivered 104 rushing yards and a touchdown in the 49ers’ win, and he can expect a deeper supporting cast this week. Rookie running back Trey Sermon is expected to make his NFL debut. He was inactive for the opener.

“I have a lot of confidence in (JaMycal) Hasty, and same with Trey (Sermon). He’ll get his opportunity now,” 49ers coach Kyle Shanahan noted. “It’s always that way in the league, especially with running backs. It’s next man up, and we expect those guys to not miss a beat.”

The Eagles have won the last two meetings with the 49ers, including 25-20 in Week 4 last October at San Francisco.

–Field Level Media

Jul 28, 2021; Santa Clara, CA, USA;  San Francisco 49ers defensive back Jason Verrett (2) during training camp at the SAP Performance Facility.  Mandatory Credit: Stan Szeto-USA TODAY Sports

49ers fear torn ACL for CB Jason Verrett

San Francisco 49ers coach Kyle Shanahan said he believes cornerback Jason Verrett tore his ACL during Sunday’s season-opening 41-33 victory at Detroit.

Verrett, in tears, limped to the locker room with assistance with the 49ers leading 41-17 and 7:28 remaining.

“It’s crushing,” Shanahan said.

Further tests will be performed to confirm the extent of Verrett’s latest injury.

Verrett, 30, started 13 games for San Francisco in 2020 after playing only six games over the previous four years (2016-19) due to knee, Achilles and ankle injuries.

A first-round pick in 2014 and a Pro Bowl selection in 2015, Verrett entered this season with 140 tackles and seven interceptions in 39 games (35 starts) with the San Diego/Los Angeles Chargers (2014-17) and the 49ers.

–Field Level Media

Aug 29, 2021; Santa Clara, California, USA; San Francisco 49ers running back Raheem Mostert (31) runs the ball against the Las Vegas Raiders in the first quarter at Levi's Stadium. Mandatory Credit: Cary Edmondson-USA TODAY Sports

49ers RB Raheem Mostert departs after knee injury

San Francisco 49ers running back Raheem Mostert was ruled questionable to return after a knee injury in the first quarter of Sunday’s opener on the road against the Detroit Lions.

After rushing for 20 yards on his first two carries, the oft-injured Mostert was immediately removed from the game after the injury replaced by Elijah Mitchell, who ran 38 yards for a touchdown in the second quarter on his third carry.

JaMychal added a 3-yard TD run later in the second quarter as the 49ers built a 21-10 lead.

Despite being deemed questionable to return, Mostert he was loosening up on the sideline shortly after being replaced.

49ers rookie Trey Sermon, a former Ohio State star running back, was among the club’s inactives for the game.

–Field Level Media

Jan 14, 2018; Minneapolis, MN, USA; New Orleans Saints center Senio Kelemete (65) against the Minnesota Vikings during the NFC divisional playoff game at U.S. Bank Stadium. Mandatory Credit: Mark J. Rebilas-USA TODAY Sports

Report: 49ers signing veteran OL Senio Kelemete

The San Francisco 49ers are signing free agent offensive lineman Senio Kelemete, NFL Network reported Friday.

The versatile veteran has made 42 career starts at multiple positions, including five starts (14 games) at left guard with the Houston Texans in 2020.

The 49ers lost backup tackle Justin Skule to a torn ACL earlier this week.

Kelemete, 31, was originally a fifth-round pick of the Arizona Cardinals in 2012.

He appeared in one game with Arizona in 2012, 57 games (22 starts) with the New Orleans Saints from 2014-17, and 30 games (20 starts) with the Texans from 2018-20.

–Field Level Media

Sep 29, 2019; Baltimore, MD, USA;  Baltimore Ravens strong safety Tony Jefferson (23) is introduced before a football game against the Cleveland Browns at M&T Bank Stadium. Mandatory Credit: Mitchell Layton-USA TODAY Sports

Report: Niners signing S Tony Jefferson

The San Francisco 49ers are set to sign former Baltimore Ravens safety Tony Jefferson, ESPN reported Monday.

Jefferson, 29, has been out of football since tearing the ACL in his left knee in October 2019.

Jefferson was in his third season with the Ravens after signing a four-year, $34 million contract as a free agent in March of 2017. The Ravens released him the following February and he sat out the 2020 season.

In seven career seasons with Baltimore and the Arizona Cardinals, Jefferson has 451 tackles, four interceptions, 8.5 sacks and 22 pass breakups.

–Field Level Media